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Can you have an allergic reaction to CBD oil?

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Contents

  1. CBD oil overview
  2. Allergies in the body
  3. Allergic reactions to CBD oil
  4. Can CBD oil help with allergies?

Whether it’s sniffling, watery eyes, itching, or asthma, many of us are all too familiar with symptoms of allergies.

According to the Asthma and Allergy Foundation of America, allergies are the No. 6 cause of chronic illness in the United States. To narrow that down,there were 19.9 million adults diagnosed with hay fever in 2017, according to the Centers for Disease Control and Prevention (CDC). It is estimated that 32 million Americans live with food allergies; more than 170 foods may lead to allergic reaction.

Considering the increasing awareness and use of cannabidiol (CBD) and the existing potential for pollen and food allergies, allergy sufferers may wonder whether they are at risk for an allergic reaction to CBD oil or whether CBD can provide treatment or relief for other types of allergic reactions.

Though there’s not much in the way of allergy research specifically for CBD oil at this point, the cannabis plant itself has been linked to allergic reactions.

“Marijuana is a plant and produces pollen and one can become allergic to the pollen and the plant, especially if one has pre-existing allergic tendencies,” said Dr. William S. Silvers, clinical professor of medicine in allergy and immunology at the University of Colorado School of Medicine.

That being said, only male marijuana plants produce pollen, and are exceedingly rare in cannabis and hemp production because they produce less oil and CBD than female plants. Therefore, a consumer’s exposure to pollen would be extremely rare.

CBD oil overview

CBD is the second-most-prominent cannabinoid derived from the cannabis plant, after the intoxicating cannabinoid THC. CBD oil, extracted from marijuana or industrial hemp, has gained popularity for its potential benefits for a number of conditions, including inflammation, arthritic pain, depression, seizures, and anxiety.

There’s not much in the way of allergy research specifically for CBD oil, but the cannabis plant itself has been linked to allergic reactions in some people. Photo by: Gina Coleman/Weedmaps

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Though research is still limited in regards to many supposed benefits, in 2018 the FDA approved Epidiolex, a CBD oral solution, to treat seizures associated with two severe types of epilepsy, Dravet syndrome and Lennox-Gastaut syndrome.

Allergies in the body

A properly functioning immune system works to protect the body from pathogens such as bacteria, viruses, and fungi, and attack these unwanted microorganisms in order to help prevent disease. In the case of allergies, the immune system reacts to plant pollen and other substances in the environment to trigger the body’s defense mechanisms. The result, depending on the type of allergy, can be a variety of symptoms, including itchy eyes, runny nose, asthma, hives, skin itching, or more severe reactions such as anaphylaxis, which can be life-threatening.

Allergic reactions to CBD oil

Humans commonly experience allergic reactions to many kinds of plant pollen. However, only male cannabis plants produce pollen, whereas female plants are more widely used for oil and cannabinoid production. Large-scale industrial hemp fields may include a variety of mature males (pollen) as well as fertilized females (oil and seeds). The impact of hemp pollen on everyday consumers, as well as the communities that work and live near these production facilities, has not been studied.

People can also develop allergies to some of the terpenes found in cannabis. For instance, researchers from the Duke University School of Medicine found that about 20% of the 100 people they tested had an allergic skin reaction to linalool, whereas 8% had reactions to limonene. These kinds of contact allergies may not be common in the general population, but individuals who are employed in the production of cannabis products and CBD oil could be more at risk.

In addition to the skin, the lungs are another target for allergic reactions to terpenes. Assessing the risk is somewhat complicated because some terpenes are irritants, whereas others, such as eucalyptol, may actually provide a protective, anti-inflammatory role and might help to control inflammatory diseases like asthma and COPD.

Dr. Gordon Sussman, an allergist in Canada and professor at the University of Toronto, said there is very little published research on CBD oil allergies.

“It’s an unknown area at this point,” he said. “But we know that cannabis sativa is an allergen and we know that it’s a common allergen.”

Humans commonly experience allergic reactions to many kinds of plant pollen. Only male cannabis/hemp plants produce pollen. Most cannabis products, including CBD oil, are made using female cannabis plants. Photo by: Gina Coleman/Weedmaps

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He said that cannabis allergies, like other forms of allergies, can worsen as exposure to the allergen continues. Most people with cannabis allergies suffer from a runny and stuffy nose (rhinitis), eye irritation (conjunctivitis), and sometimes wheezing, Sussman explained. But there have been cases of more severe reactions such as anaphylaxis, which have primarily resulted from ingestion of hemp seeds.

According to a letter entitled “Marijuana and stoned fruit,” written by medical doctors from the University of California, San Diego, and published in the Annals of Allergy, Asthma, and Immunology on Feb. 2, 2018, a 24-year-old man who smoked marijuana daily visited their allergy clinic two weeks following an anaphylactic reaction after eating yogurt with hemp seeds.

“This was his first known ingestion of hemp seeds. Immediately after consumption, he developed oral pruritus [itching] that progressed to shortness of breath, facial swelling, and pre-syncope [sensation prior to fainting],” the letter stated.

Those with food allergies may also be susceptible to cross-reactivity.

“You can have a cross-reaction with certain foods that share certain antigens, certain components, with the cannabis plant itself,” Silvers said.

Such foods may include tomatoes and stone fruits containing pits such as peaches, he said. It’s a similar cross-reactivity to what is seen in people with ragweed allergies who might experience symptoms such as itchy mouth if they eat fruit in the melon family, he added.

“The same thing goes with cannabis and tomatoes and peaches and almonds and a number of other foods … eggplant, grapefruit, apples,” Silvers said.

CBD oil dropper

There is no clinical evidence CBD oil can help allergies. Photo by: Gina Coleman/Weedmaps

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CBD oil dropper

A 2013 study from the “Internal Archives of Allergy and Immunology” tested 21 patients with food allergies for reactivity to cannabis lipid transfer proteins (LTPs), which are probable allergens. Twelve of the 21 test subjects were allergic to cannabis, and all 12 had more severe reactions to food allergy than those without a cannabis allergy. A 2008 study, also from “Internal Archives of Allergy and Immunology,” tested 32 subjects for an allergic reaction to cannabis LTPs, as well as tomato, peach peel, and pollen extracts. The study found that all test subjects sensitive to tomato allergens were also sensitive to cannabis. There was also cross-reactivity noted with peach peel.

Silvers said that the type of allergic reaction depends on the type of exposure. In addition to cannabis pollen allergies and food-based allergies, skin allergies are also a possibility.

“Touching the plant can very easily develop a dermatitis, itching, and skin reactions,” he said.

Can CBD oil help with allergies?

While there isn’t much research supporting the idea that CBD oil can help the discomfort associated with common allergy symptoms, there is some research related to its general effects on inflammation, which is part of the body’s allergic reaction process.

A 2011 research report published in the journal Free Radical Biology and Medicine examined the potential role of CBD in various inflammatory-type conditions. George W. Booz, a professor in the department of pharmacology and toxicology at the University of Mississippi Medical Center, concluded in the report: “Inflammation and oxidative stress are intimately involved in the genesis of many human diseases. Unraveling that relationship therapeutically has proven challenging, in part because inflammation and oxidative stress ‘feed off’ each other. However, CBD would seem to be a promising starting point for further drug development given its antioxidant (although relatively modest) and anti-inflammatory actions on immune cells … .”

According to Silvers, there is no clinical evidence CBD oil can help allergies and, while experimental laboratory research suggesting anti-inflammatory effects exists, there’s no clinical patient substantiation.

Can you have an allergic reaction to CBD oil? Copy article link to clipboard. Link copied to clipboard. Contents CBD oil overview Allergies in the body Allergic reactions

Can Someone Be Allergic To CBD?

By Spike Bowan | June 10, 2018

Is It Possible To Have An Allergy To CBD?

With CBD oils and products becoming more popular and relevant, there have been more cases of people showing adverse symptoms to CBD. Some of these symptoms are considered side effects or sensitivity to CBD, while other symptoms are allergic reactions to CBD.

An allergic reaction can occur from any product the body sees as an allergen. The most common allergies occur from foods, medications, insect stings, pollen, and pet dander. Since CBD is derived from the cannabis plant called hemp, CBD contains properties like pollen and histamine that can cause allergic reactions. Although allergies to CBD are rare, it is possible for people to be allergic to CBD. CBD has also been known to help with allergies due to the antihistamine and anti-allergenic properties.

An allergic reaction to CBD oil can range from an itchy nose to breathing problems. It is important to stop using CBD at the first sign of any negative side effects from CBD. To understand the difference between being allergic to CBD or exhibiting side effects from CBD, it is important to understand the different symptoms of both.

What are the side effects of CBD?

There are a handful of side effects that some people might experience from using CBD oil. These side effects are not considered allergic reactions to CBD, but might be caused by using too much CBD at once or due to a sensitivity to CBD. Some common side effects of utilizing CBD oils are:

  • Interactions with other medications
  • Dry mouth
  • Increased tremor in Parkinson’s patients
  • Low blood pressure
  • Lightheadedness
  • Drowsiness

What happens if I’m allergic to CBD?

According to the American Academy of Allergy, Asthma, and Immunology, someone with allergies to CBD can exhibit symptoms after inhaling, touching, smoking, or consuming any products containing CBD. An allergic reaction happens when the body’s immune system overreacts to a substance that the body sees as a threat. To protect the body, the immune system will produce antibodies called Immunoglobulin E, which cause the symptoms of an allergic reaction. These reactions vary depending on the person’s immune system and the number of Immunoglobulin E their body releases. An allergic reaction does not always occur on the first exposure to the allergen and allergies can change over time.

Since CBD is extracted from hemp plants, most allergic reactions to CBD are similar to seasonal allergies or allergies to pollen and fungi. These symptoms should go away if you stop using CBD. Some common allergic reaction symptoms to CBD oils are:

Congestion and dry cough

Runny nose and sneezing

Eye irritation and redness

Skin reactions may also occur after consuming CBD or using CBD as a topical ointment. Skin reactions to CBD include:

Inflammation and redness

Although rare, anaphylactic shock is a life-threatening allergic reaction that can be caused by an allergic reaction to CBD oil. When someone is experiencing anaphylactic shock, their body is flooded with chemicals that cause their airways to narrow and restrict breathing. If the following symptoms are being exhibited, it is strongly advised to seek medical attention immediately:

Difficulty breathing, shortness of breath, or wheezing

Dizziness or fainting

Loss of consciousness

How are CBD allergies diagnosed?

Allergies to CBD can be diagnosed by a doctor through two methods: a skin prick test and blood tests. A skin prick test is simple and the results are quick, but it is not as accurate as a blood test.

A skin prick test is when a diluted allergen, such as CBD, is applied to the skin with a needle. After 15 minutes, if the location where the allergen was applied appears to be inflamed, red, or itchy, the person may be allergic to CBD.

With a blood test, a sample of blood is drawn to see if there are any present antibodies to CBD. If there are more antibodies than expected, the person is most likely allergic to CBD.

If you are exhibiting any of these side effects or allergic reactions, please stop using CBD and seek medical attention if the symptoms worsen. For those that are worried they might be allergic to CBD, allergy tests are an option for you. Understanding the differences between side effects and allergy symptoms may help you decide if CBD is right for you.

The content on this site is not intended to be a substitute for professional medical advice, diagnosis or treatment. While research has shown that CBD has the potential to help provide beneficial outcomes for several complaints, it is advisable to seek the advice of a physician or other qualified healthcare provider when you have questions regarding any medical condition and when starting, augmenting or discontinuing any existing health routine.

Can Someone Be Allergic To CBD?