Can cannabis help with glaucoma?
Glaucoma is a common eye condition that often causes optical nerve damage and when left untreated can lead to blindness. In the US, about three million Americans live with glaucoma; globally, the figure is close to 60 million. Glaucoma is recognized as one of the leading causes of irreversible blindness.
Since 1980, surgical procedures and treatments have improved significantly, cutting the risk of developing blindness nearly in half. Nonetheless, while treatment has improved, the number of effective topical drugs remains limited.
Almost universally recognized in medical marijuana states as a qualifying condition, increasing numbers of people have turned to cannabis to help their condition. But is marijuana actually good for glaucoma?
Given the improvement of existing glaucoma treatments, do the benefits of medical cannabis outweigh the potential side effects or risks? Likewise, given the vital role the body’s endocannabinoid system (ECS) plays in disease, what promise does the future hold for developing cannabinoid-derived medications to help with glaucoma?
What causes glaucoma?
Evidence increasingly suggests glaucoma—now widely considered to be a neurodegenerative condition—has a connection to other neurodegenerative diseases like Alzheimer’s disease. Glaucoma appears to be a significant predictor of Alzheimer’s. A precise cause of glaucoma, however, remains a mystery and continues to elude the scientific community.
Current glaucoma treatment options
Because intraocular pressure (IOP) influences the onset and progression of glaucoma, ophthalmologists prescribe treatments that target intraocular pressure. In fact, the only way to prevent vision loss or eventual blindness is to lower IOP levels.
Depending on the severity and progression, ophthalmologists may treat glaucoma with medications such as prescription eye drops, or, if necessary, surgery.
Can marijuana be used for glaucoma treatment?
Going back to the 1970s, studies have shown that cannabinoids can alleviate glaucoma-related symptoms because they lower intraocular pressure (IOP) and have neuroprotective actions. For example, this 1971 study found that ingestion of cannabis lowers IOP by 25-30%.
Despite the findings from early research, few ophthalmologists support the use of medical marijuana for patients with early to mid-stage glaucoma. The main issue ophthalmologists have is that potential adverse effects —particularly when smoking weed—might outweigh short-term benefits. For example, smoking can lead to unstable intraocular pressure, thereby increasing the risk of permanent vision loss.
Further, because its therapeutic effects on glaucoma are short-term, patients would have to consume cannabis frequently—once every three to four hours.
Doctors claim that because glaucoma needs to be treated 24 hours a day, patients would need to consume cannabis six to eight times over the course of a day to achieve consistently lowered IOP levels. Such frequency is hard to maintain and could increase the risk of developing a cannabis use disorder.
However, when it comes to late-stage glaucoma, ophthalmologists are more inclined to embrace cannabis to help with the condition. In later stages of glaucoma, it’s less about directly targeting glaucoma and more about alleviating the accompanying symptoms.
According to ophthalmologist Andrew Bainnson, MD, “We’ve known for some time that medical marijuana is very effective for treating nausea and pain, but not so much for glaucoma. There are some patients with end-stage pain and nausea who may benefit [from medical marijuana], but not from the glaucoma point of view.”
Can cannabis-based treatments play a greater role in the future?
The body’s endocannabinoid system (ECS), is one of our most important physiological systems. Nearly every aspect of our health—including inflammation, immune response, neuroprotection, and pain modulation—are all dependent on the ECS. Given the vital role of the ECS, particularly in neuroprotection and inflammation, cannabinoid-based medications could be immensely useful in treating and preventing glaucoma.
Cannabinoid receptors are prominent in ocular tissues responsible for regulating intraocular pressure. Cannabinoid-derived medications could be developed to serve two roles: lower IOP and protect retinal cells.
Evidence suggests two cannabinoid agonists—WIN55212-2 and anandamide—and several cannabinoids, including CBD and CBG, may be good candidates to develop as therapeutic agents, particularly because even when administered topically (directly to the eye), they are well tolerated.
Challenges with treating glaucoma with cannabis
However, challenges persist: Oral preparations are not good because bioavailability is poor and absorption unpredictable. Inhalation isn’t ideal because effects don’t last long enough.
That leaves topical preparations. But cannabis eye drops—while superior to oral and inhalation administration—do a poor job penetrating intraocular tissues.
The future of medical marijuana and glaucoma
While cannabis, as it is administered today, may not be an ideal treatment for glaucoma, the development of cannabinoid-derived medications represent a promising future direction. And, whether or not cannabis is an ideal glaucoma treatment, there are some people who swear by it as a godsend for their condition, while others consume it as an adjunct to therapy, but not as their primary treatment.
If you or someone you know has successfully used cannabis to treat glaucoma, share your experience with us in the comments section.
This post was originally published on September 22, 2016. It was most recently updated on March 13, 2020.
Glaucoma is a serious eye condition affecting over 3 million Americans. Learn more about marijuana being used as a potential treatment option.
Cbd oil and glaucoma
CBD, short for a chemical in the cannabis plant called cannabidiol, has become all the rage over the past year. Available in oils, sprays, creams, and even bath bombs and dog treats, CBD does not make you high, unlike its well-known cannabinoid cousin, THC (tetrahydrocannabinol).
Often touted as a magical elixir, CBD is being marketing as a treatment for just about everything, including anxiety, insomnia, pain, and even cancer. According to AARP, baby boomers are fueling the popularity of CBD and using it as a treatment for pain, arthritis and other age-related health problems.
Glaucoma, however, has been taken off the list of conditions that may benefit from CBD. The American Academy of Ophthalmology recently reported that a new study proved CBD may worsen glaucoma, which is a leading cause of blindness in the U.S.
The study suggests that CBD doesn’t lower eye pressure, it raises it, which is problematic because high eye pressure is the primary risk factor for glaucoma. High eye pressure from glaucoma damages the optic nerve, which is responsible for allowing us to see by transmitting visual information to the brain. Increased eye pressure damages the nerve, leading to permanent vision loss.
For the study, researchers tested an eye drop in rats that contained CBD. They found that the CBD drops raised pressure inside the eyes by 18% for at least four hours after the drops were applied. They also tested eye drops that contained only THC, with no CBD, and found that eye pressure decreased temporarily by up to 30% within eight hours.
The researchers also found that CBD and THC affect eye pressure differently in male and female rats. Males who received THC had a much larger decrease in their eye pressure than females, which may mean that there are gender differences in how the compound acts on the brain.
What does this all mean for people who either have or are at risk of developing glaucoma? It means they should avoid using CBD products to treat glaucoma until more research can be done.
For people who don’t have glaucoma and are considering using CBD for other conditions, it’s important to note that research of CBD is in its infancy, and the purity and dosage of some CBD consumer products may not reliable. In addition, CBD can have negative interactions with many medications, so patients with any eye conditions or diseases should talk to their ophthalmologists before taking it.
The ophthalmologists at Baptist Eye Surgeons continue to recommend that patients stick with their currently prescribed treatment of oral medications or eye drops, and come in for regular visits so that their eye pressure and long-term care can be monitored.
The doctors at Baptist Eye Surgeons specialize in detecting and treating diseases of the eye, including glaucoma. With offices in Knoxville, TN and Morristown, TN, Baptist Eye Surgeons is an ophthalmological practice dedicated to providing exceptional eye care to patients whose needs range from routine comprehensive eye examinations to complex eye surgeries. To learn about our specialities and our doctors, visit our website. Call us at 865-579-3920 for more information, or visit us online to schedule an appointment.
Glaucoma is not a condition that CBD oil helps. According to reports from the AAO, a recent study proved CBD may actually worsen glaucoma or high eye pressure.