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CBD Oil for Nausea: How to Get Rid of Vomiting And Upset Stomach

CBD Oil for Nausea: How to Get Rid of Vomiting And Upset Stomach

Although research is limited, some experts believe that cannabidiol (CBD) may provide relief for nausea and vomiting. The use of CBD for nausea is typically used as a treatment for patients undergoing chemotherapy or radiation. However, due to the federal legalization of hemp-derived CBD and rapid market growth, those suffering from short-term or chronic nausea are also finding relief using CBD.

Is CBD good for nausea?

Nausea is commonly defined as the sensation of an urge to vomit. Nausea can be short-lived or prolonged and stems from various causes, such as a sensitivity to motion or certain foods, medications, or the effects of certain medical conditions.

Research suggests there is a direct link between your body’s endocannabinoid system (ECS) and the areas of the brain that control nausea and vomiting. The ECS consists of cell receptors that bind with cannabinoids to regulate a variety of functions, including immune response, communication between cells, appetite and metabolism, memory, and more.

Animal studies suggest that CBD might help regulate nausea by interacting with serotonin receptors. Serotonin is a chemical nerve cells produce that impacts every part of the body, from emotions to motor skills. Its biological function is responsible for moderating mood, cognition, reward, learning, memory, and numerous physiological processes such as vomiting and vasoconstriction (the constriction of blood vessels).

Even in small doses, the non-intoxicating cannabinoid CBD has been shown to help alleviate both nausea and vomiting based on how it interacts with serotonin-releasing receptors. CBD has also shown promising signs of easing anxiety, which can help manage chronic nausea.

Best type of CBD for nausea

Human studies also report that a combination of CBD and THC may provide relief from nausea, especially for patients going through chemotherapy. THC appears to relieve nausea and vomiting by stimulating the CB1 receptors in the brain and gastrointestinal tract. Activating these receptors also improves appetite. When combined, CBD helps counteract the intoxicating effects of THC.

World-renowned neurologist and cannabinoid researcher Dr. Ethan Russo theorizes that THC, CBD, and other naturally-occurring compounds found in cannabis can be more effective when consumed together. He refers to this as the “entourage effect,” meaning the compounds work in synergy to amplify the therapeutic properties of each individual cannabinoid.

Because the research indicates that THC is more effective at reducing nausea than CBD, full-spectrum CBD products are your best bet for controlling nausea. Full-spectrum CBD for nausea contains all of the beneficial cannabinoids, terpenes, and flavonoids found in cannabis, including small amounts of THC (less than 0.3% in federally legal products). If you are new to THC or do not want to experience any intoxicating effects, broad-spectrum CBD removes THC, and CBD isolate removes everything except CBD.

For immediate relief, smoking or vaping CBD reaches your bloodstream faster than alternative consumption methods. On the other hand, edibles may take longer to hit, but the effects stay in your system longer than inhalation. CBD oil offers more versatility. You can mix it with food or drink to digest it the same way as an edible, or you can drop it under your tongue to expedite the effects. There are no up-to-date studies on the effects of topical CBD to relieve nausea. Topicals are typically used to alleviate pain and sore muscles in a specific area of the body.

Nausea is a horrible thing to experience; it is distracting, highly uncomfortable. Does weed and CBD help nausea? Find out more in our article.

Nausea and CBD Oil: Research, Benefits, and Dosage

Written by Jason Brett — Edited by Cathy Rozyczko on April 1, 2021 — Reviewed by Dr. Rosie Carey, GP

Over the course of a lifetime, it’s a given that everyone will experience nausea at least a few times. It is a built-in biological function that is debilitating at worst and an inconvenience at best. In most cases, nausea can be resolved with fresh air, a glass of water, and a calm environment. But what if your nausea doesn’t subside so easily? Can CBD oil help?

For many people, nausea can be an overwhelming constant, an accepted symptom of illness, or even a side effect of medical treatment.

Advances in modern medicine have led to a wide range of treatments for a wide range of conditions. Unfortunately, those treatments often carry side effects, with nausea being one of the most common. Many times patients are left with few options—the medicine is necessary and the nausea becomes something you just have to live with.

But, the truth is, you don’t have to just accept it. Using CBD oil for nausea relief can be an effective, natural, way to regain control of your life.

For our recommendations on which CBD oil products are best for nausea, check out The Best CBD For Nausea: A Buyer’s Guide.

Benefits of Using CBD Oil for Nausea

There are hundreds of cannabinoids present in cannabis and hemp plants; cannabidiol (CBD) is just one of them. CBD has been found to offer many potential benefits to human health without causing the intoxication most commonly associated with THC and marijuana consumption. In other words, CBD will not get you high.

By working with the body’s cannabinoid receptors, CBD has been found to produce a range of beneficial effects, including reducing nausea and vomiting.

Most anti-nausea and antiemetic drugs are a saving grace for people who experience debilitating nausea. But because nausea can be caused by a variety of factors, and because the science behind what causes nausea is not clear, there are many different medications that can be prescribed, and finding the right one can require a bit of trial and error. CBD oil may be able to eliminate some of this back and forth.

In chemotherapy, for example, there are three different types of antiemetics available, yet each has a completely different function. One targets dopamine receptors; another, serotonin receptors; and the last targets NK1 receptors. What works for one person may not work for another. And what’s worse, many of these medications carry side effects. CBD oil does not have complicated side effects and may present as a better solution.

Anti-nausea/Antiemetic Medication Side Effects of Medication CBD Oil for Nausea Potential Interaction of Medication + CBD Oil
Ondansetron (Zofran) Diarrhea; constipation; headache; fever; lightheadedness; dizziness; weakness; drowsiness; continued nausea and vomiting CBD oil can relieve nausea without causing these side effects No known interactions between Ondansetron and CBD oil
Granisetron (Kytril) Diarrhea; constipation; fever; dizziness; headache; weakness; loss of appetite; continued nausea and vomiting CBD oil can relieve nausea without causing any of these same side effects No known interactions between CBD oil and Granisetron
Dolasetron (Anzemet) Headache; lightheadedness; swelling in hands and feet; slow heart rate; decreased urination; continued nausea and vomiting CBD oil can relieve nausea without causing these same side effects No known interactions between CBD oil and Dolasetron
Dexamethasone (Decadron; Dexasone) Increased appetite; mood changes; insomnia; headaches; dizziness; skin rash or discoloration; bruising; continued nausea and vomiting CBD oil can stop nausea without causing these same side effects No known interactions between Dexamethasone and CBD oil
Diphenhydramine (Benadryl) Irritability; dry mouth; blurred vision; dizziness; drowsiness; continued nausea and vomiting CBD oil can relieve nausea without causing most of these side effects;Could potentially cause dry mouth There are possible interactions between CBD oil and diphenhydramine;Never use together without first consulting a doctor
Dimenhydrinate (Gravol) Drowsiness; hyperactivity; headache; blurred vision; ringing in the ears; dry mouth; trouble with coordination CBD oil can relieve nausea without causing a majority of these side effects;Possibility for dry mouth There are possible interactions between CBD oil and dimenhydrinate;Never use together without first consulting a doctor
Lorazepam (Ativan) Depression/thoughts of suicide; muscle weakness; headache; blurred vision; loss of balance; continued nausea and vomiting CBD oil can relieve nausea without causing any of these same side effects There are possible interactions between CBD oil and lorazepam;Never use together without first consulting a doctor
Prochlorperazine (Stemetil) Anxiety; insomnia; dry mouth; stuffy nose; blurred vision; dizziness; drowsiness; continued nausea and vomiting CBD oil can relieve nausea without causing similar side effects;Dry mouth can occur There are possible interactions between CBD oil and prochlorperazine;Never use together without first consulting a doctor
Haloperidol (Haldol) Involuntary movements; hyperactivity; tiredness; weight gain; insomnia; dry mouth; continued nausea and vomiting CBD oil can relieve nausea without causing most of these side effects;You may experience dry mouth There are possible interactions between CBD oil and haloperidol;Never use together without first consulting a doctor

As you can see, many of these drugs carry detrimental side effects including continued nausea and diarrhea. Considering this, it isn’t surprising that people are looking to CBD oil as a potentially safer, more effective option for nausea relief.

Effectiveness of Using CBD Oil for Nausea

Nausea is complicated and the science is unclear about what exactly causes it. But, what is starting to become clear, is that CBD oil may be able to relieve nausea.

In fact, one of the medications approved for use in chemotherapy-related nausea is Nabilone, a synthetic cannabinoid. Nabilone is used after all other medical treatments have failed. This particular drug is actually a synthetic THC—not CBD—but it points to the fact that the solution to nausea may lie in the endocannabinoid system.

While the causes of nausea remain a mystery, one theory suggests that it is caused by an increased release of serotonin. Serotonin is a neurotransmitter that, when present in large amounts, can leave you feeling queasy. CBD oil is able to counteract this effect by interacting with the receptors responsible for releasing serotonin into the body.

CBD Oil for Chemotherapy-Related Nausea

Nausea induced by chemotherapy treatment can present itself in various forms, namely as symptomatic nausea, caused directly by the impact of chemotherapy drugs on the body, and anticipatory nausea, your body’s preemptive response to situations that have triggered nausea or vomiting in the past.

While symptomatic nausea can be treated with antiemetics, this is not the case with anticipatory nausea. A known experience in patients who have suffered from bouts of post-treatment nausea in the past, anticipatory nausea begins before any physical nausea is felt. For those undertaking chemotherapy treatment, CBD oil may provide relief from the symptoms of both symptomatic and anticipatory nausea.

It is thought that CBD oil reduces the experience of nausea by impacting the 5HT1A, or serotonin, receptors in the brain, which are thought to cause nausea and vomiting. When CBD binds to these receptors, signals to reduce serotonin production are sent to the forebrain. By blocking the release of serotonin, CBD is able to stop nausea at its source.

A study on THC and CBD’s effect on anticipatory nausea specifically also showed promising results. In the study, shrews were exposed to cues while vomiting was induced to create a cognitive connection between the two. When the test subjects were given THC or CBD before being exposed to the same cues that were tied to episodes of nausea and vomiting, they did not experience anticipatory nausea.

There is a great deal of research that still needs to be done to understand the impact CBD oil can have on nausea, and the mechanisms behind its anti-nausea and antiemetic properties. But at the moment, using CBD oil for nausea may be just as effective as using traditional medications, minus the harsh side effects.

How to Take CBD Oil for Nausea

Before you consider taking CBD oil for nausea, it is important to first speak to your doctor. While generally safe, CBD oil can interact with a few common medications and so you will want to make sure you’re not facing any risks.

Once you have been cleared to use CBD oil, you will need to decide how you want to take it. In most cases, the delivery format you choose will depend on your needs and personal preferences. For conditions like nausea, however, some products will make more sense than others.

Using a CBD vape, CBD flower, or CBD oil tinctures or drops, can help provide relief from the sudden appearance of nausea.

CBD vape oil and CBD flower are inhaled, meaning the CBD can avoid the digestive system and is absorbed directly into the lungs. The effects appear within minutes, offering the fastest nausea relief. The downside to using a CBD vape or flower is the benefits do not last long (typically 30 minutes to an hour) and it may be necessary to take another dose for relief from chronic nausea. And, of course, it may not always possible or desirable to vape or smoke.

This is where CBD oil drops and tinctures can be effective. These products bypass digestion as well and are absorbed through the skin under the tongue. They do not work as quickly as CBD vapes or flower, but they are the next best thing. You can expect relief within 30 minutes and the benefits to last anywhere from 2-4 hours. CBD drops and tinctures provide the best dosage control, giving you the ability to measure your dosage down to the literal drop.

CBD oil capsules and edibles can also be used as part of a daily supplement routine. However, because they must pass through the digestive system, they take the longest for your body to process. Too, if you have a sensitive stomach, adding more digestables to the mix may not be an ideal option.

CBD Oil Dosage for Nausea

There is no universal dose of CBD oil for nausea. Because no two people will respond in exactly the same way, it is best to begin by following the recommended serving suggestion that comes with your CBD oil product.

If you’re looking for personalized dosage advice, talk to a cannabis doctor who can assess your specific condition and give you a more tailored recommendation.

Or, you can go by our suggestion if your CBD product doesn’t come with dosage instructions. At CBD Oil Review we have analyzed hundreds of products and come up with a standard serving suggestion:

The CBD Oil Review Serving Standard is 25mg of CBD, taken twice daily.

If you are not getting results from this amount, we recommend increasing the serving size by 25mg every 3-4 weeks until you find relief.

To better understand CBD oil dosage, you can read our tips here.

If you’re ready to try CBD for nausea, but don’t know where to start or which products to buy, check out our buyer’s guide: The Best CBD For Nausea.

If you’ve enjoyed this read and would like to learn more, check out:

Learn about the research, benefits, dosage and recommendations for using CBD oil (cannabidiol ) to manage nausea, both anticipatory and symptomatic.