Research on CBD Oil for Asthma
Research on CBD Oil for Asthma and many other diseases is currently taking place in science labs around the world. In developed countries alone, atopic diseases such as asthma and dermatitis affect nearly 20% of the population. In the mid-60s scientists were able to synthesize the two most important cannabinoids, namely Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD). CBD is the main non-psychoactive cannabinoid and has been shown to have therapeutic effects across numerous pathological conditions. These include neuropsychiatric illnesses, addiction, brain inflammatory disorders, mood disorders, skin conditions, etc., without significantly activating the main endocannabinoid receptors. Due to these beneficial effects and low toxicity even when administered chronically in humans, scientists have been considering CBD for asthma as a feasible novel treatment.
What is asthma?
Asthma is described as a disorder of the conducting airways which causes easy and excessive contraction of the said airways in response to numerous internal and external stimuli.
This hyper-responsiveness of the airways is portrayed along with heightened irritability of airways and uncontrollable mucus secretion. Asthma has different clinical expressions that are accentuated through various environmental factors that affect the airways, causing chronic inflammation. A number of other factors are involved in this phenomenon, for example, edema, smooth muscle contraction, and airway remodeling.
As mentioned above, CBD, the recently discovered component of the Cannabis sativa plant, has shown to exert potent analgesic, anti-inlfammatory and immunomodulatory effectsthat could prove effective in the management of atopic disorders such as asthma. Cannabinoids exert these effects through in ways that are still unknown and scientists are busy trying to get this information.
Recently, studies have shown the involvement of CBD in control receptors associated with the control of inflammatory response, expression, and genetic transcription. CBD has also shown numerous functional effects in the treatment of various diseases, including: colitis, sepsis-related encephalomyelitis, and inflammatory lung diseases. Furthermore, it has been demonstrated that CBD is well tolerated in both animal models and human clinical trials, without significant side effects.
Current Asthma Treatment
The treatment of asthma remains a huge problem for the medical community, not to mention the patients suffering from this acute condition. Therapy often involves a combination of different medicationssuch as: bronchodilators, leukotriene modifiers, corticosteroids, and in the recent years, target-directed therapies including: anti-IgE and anticytokines.
That being said, all of the mentioned treatments have their advantages and limitations, such as the incidences of adverse side effects. Additionally, those suffering from drug-resistant asthma, despite intensive treatment, still suffer. As a result, there is a clear need to find new ways of controlling this respiratory disease.
Evidence of CBD Oil’s Efficacy for Treating Asthma
A study tested the effects of CBD on guinea-pigs induced with an antigen with an asthma-like reaction in order to test its ability to interfere with the effects of the antigen. In the results, the scientists concluded that the use of CBD to target cannabinoid receptors could prove a novel preventative therapeutic method for controlling asthma.
Another review focused on the effects of cannabinoids on allergic/immune reactions, neuroinflammation and inflammation pain. In their conclusions, the scholars noted that the presence of endocannabinoid components in the central nervous system, combined with high levels of CB1 expression, is proof that the endocannabinoid system is an important regulator of neuroinflammation and may be used as a possible drug target for illnesses that are made worse by inflammation such as asthma.
In the development of inflammatory diseases such as asthma, there has to be some sort of interaction between T-cell and allergens. A different animal study evaluated the anti-inflammatory potential of CBD in 8-week-old Wistar rat models induced by asthma via ovalbumin (OVA) and treated with 5 mg/kg, i.p. CBD. The results showed the CBD was able to decrease the serum levels of all analyzed cytokines except for IL-10 levels. This demonstrates that CBD might be a potential new therapy for controlling inflammatory response in asthmatic patients.
The Mechanism Behind CBD Oil’s Therapeutic Effects on Asthma
Scientists are still grappling to find the exact methods through which CBD exerts its many therapeutic effects. Taking this into account, there are a few studies that have been trying to shed some light with regards to this matter.
For instance, a group of scientists recognized that even though neurogenic inflammation through the activation of C fibers in the airway is heavily involved in the development of asthma, their regulatory mechanism was still unknown. In a bid to establish these facts, they tested the how cannabinoids are able to modulate inflammatory reactions using guinea-pigs as models.
Furthermore, anandamide and palmitoylethanolamide inhibited the capsaicin-induced release of substance P-like immunoreactivity from airway tissues in the sample. Nevertheless, anandamide did not inhibit capsaicin-induced bronchoconstriction. These findings suggest that CBD works to reduce inflammation in asthma by inhibiting the activation of C fibers through CB2 receptors and maxi-K+ channels and may present a novel target for treating asthma and similar conditions.
Side Effects of Using CBD for Asthma
Generally, the side effects of using CBD oil for asthma and other atopic conditions is very limited. That being said, according to information from other studies, CBD has a high safety profile, with minimal and mild side effects.
Some of these known side effects include:
- Inhibition of hepatic drug metabolism
- Dry mouth
- Increased tremor in patients with Parkinson’s at high dosages
- Decreased appetite
- Light headedness at high dosages
More research is needed before we can understand the full efficacy of CBD oil as a treatment for asthma. More so, it will be a while until a conventional CBD for asthma medicine hits the shelves. But as of now, we can only remain hopeful that soon, we will know exactly how CBD works to modulate the effects of asthma.
Below is a list of all the relevant case studies, reviews, research and anecdotal reports concerning the effects of CBD on asthma. We update the information on this page regularly, so, come back and you will be the first to know in case of any new updates or developments in this field.
Research Studies on the effects of CBD oil to treat Asthma:
Research on CBD Oil for Asthma
CBD for Asthma: Is CBD good for Asthma?
Statistics based on research from WHO 1 estimates, 235 million people suffer from asthma. Asthma is the most common chronic disease among children. That’s not all, this percentage is rapidly growing over time. Although asthma is not classified as an exhausting condition, it could as easily turn your world upside down. Here is a breakdown of what this ailment is and a common remedy for asthma.
What is Asthma?
Asthma is a chronic disease 2 that affects a person’s airways thus making it very difficult for them to breathe. This ailment entails inflammation in an individual’s air passages that prompt them to contract temporarily. This contraction occurs in air passages that supply oxygen to your lungs hence creating breathing difficulties.
Asthma has become a very serious condition. This is supported by the fact that almost 2 million people suffering from this condition visit the hospital each year.
Is CBD good for Asthma?
CBD provides a really strong anti-inflammatory agent. The main reason why CBD is good in treating asthma is that it is very powerful in managing aggrandized inflammatory responses in the patient’s body.
Generally, using CBD daily can help your system to control asthma more easily and reduce mitigate muscle spasticity and pain caused by the condition.
Mitigating Muscle Spasticity
CBD plays a significant role in mitigating muscle spasticity. Bronchospasm (bronchial spasms) are sudden contractions of the lung muscles. This constriction leads to breathing difficulties with the subjects’ reactions ranging from mild to extremely severe cases. The hallmark sign or symptom of asthmatic complications is the stated complication- Bronchospasms. This is where CBD can help. CBD has proved, not only in one case but several others to be very effective in reducing or completely eradicating muscle spasms. The advantage of using CBD for the treatment of asthma is the fact that it is very safe to consume. Previous users have experienced zero or minimal side effects after using it to treat this condition. You only have to follow all the prescription instructions that have been given if you want to achieve the best results.
Reliable researches and studies conducted have proved that it has something to do with CBD found from certain specific cannabis strain. CBD contains effective muscle spasm relief effect. This is very significant in hitting the bronchial muscles. In the end, the effect is a relaxed body and better breathing. By relaxing your lung muscles, the airways supplying oxygen to the heart expand, allowing easy breathing.
CBD also plays a very vital role in relieving asthma-based pains. If you are still not sure about the effectiveness of CBD on asthma, try not to forget about its ability to relieve pain. Even though pain isn’t among the primary symptoms of asthma, over three-quarters of people dealing with asthma attacks complain of chest pains.
For folks with severe asthma attacks, these pains can become pretty uncomfortable and even get to excruciating levels. It is, however, paramount to keep in mind that there aren’t any pain receptors present in a human being’s lungs. The pains experienced by people dealing with asthma arise from the difficulties they face in breathing.
Although there haven’t been any studies yet that specifically look at the effectiveness of CBD in abolishing asthma-related pains, it is crystal clear that it alleviates muscle spasticity and pressure from the lungs. This, by itself, is good enough in curbing these pains when breathing as it allows a smooth flow of air, lessening the stress applied to the muscles.
The Endocannabinoid System & Asthma
Research on the impacts and effects of different drug types on the endocannabinoid system has been conducted for quite a while now. This research has hit many barriers over the period of time it has been going on. Eventually, it was established that this system plays a very major protective role against certain diseases with asthma being one of them.
CBD Dosage For Asthma
We recommend the Step-Up method to find out the ideal dosage. Leinow & Birnbaum recommend in their book “CBD: A patient’s guide to Medical Cannabis” 3 to start with a microdose for asthma The dosage can be carefully increased to a standard dosage.
For more details on dosage, read our article on CBD dosage.
How can I use CBD to treat Asthma?
The most recommended mode of using CBD to treat asthma is by making use of CBD oil. If you choose to take CBD oil orally, simply put some drops underneath your tongue and hold it until it gets fully absorbed in your mouth. Don’t swallow it right away, rather wait for it to be absorbed. This makes digestion and absorption much easier. You can also take it as capsules or mix it with a drink.
What is Research Saying About Using CBD For Asthma?
Over the last few years, many medical studies focused on researching the effectiveness of CBD in asthma 4 treatment have been conducted by several research institutions and organizations all over the world.
Generally, studies undertaken endorse the effectiveness of CBD in the treatment of asthma. They prove that for individuals suffering from Asthma, embracing the idea of using CBD to treat asthma 5 is a step closer to properly managing this disease. The studies were conducted by various professionals, institutes and organizations that support CBD’s effectiveness in handling asthma. This is a clear indication that it is currently one of the safest treatment methods for this condition.
The reason why CBD is good in treating Asthma is that it's powerful in managing aggrandized inflammatory responses in the patient’s body. Read more here.