How long does it take CBD to work?
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- How does CBD interact with the body?
- The method of consumption matters
- Dosage matters
- How long does it take CBD to get out of your system?
So, you’ve heard about cannabidiol (CBD) oil possibly working wonders for chronic pain relief, anxiety, and many other conditions. You finally sit down, unscrew the cap from the CBD oil bottle, and prepare to set out on a soothing journey guided by this non-intoxicating cannabinoid. After taking a few drops of CBD oil or applying a CBD-infused topical to the skin, you might start to ponder the following questions:
- How long does it take for CBD to work?
- How long will the effects of CBD oil last?
More clinical research is required to answer these questions with unwavering confidence, but we can still look at how CBD interacts with the body to come up with well-educated estimates.
How does CBD interact with the body?
CBD interacts with the brain and body through a number of different mechanisms, creating a complex relationship that still merits further research before we can fully understand how this cannabinoid might relieve certain ailments.
Upon entering the system CBD interacts with a wide range of proteins in the body and central nervous system. A key part of this interaction takes place within the endocannabinoid system (ECS), specifically the CB1 and CB2 cannabinoid receptors. Unlike THC, which is the intoxicating cannabinoid that binds to these receptors and creates the stoned effect, CBD actually has an inverse effect. When cannabidiol is introduced to the ECS, it inhibits the absorption of anandamide, a natural cannabinoid that regulates pain.
When cannabidiol is introduced to the endocannabinoid system, it inhibits the absorption of anandamide, a natural cannabinoid molecule that regulates pain. Photo by: Gina Coleman/Weedmaps
CBD also interacts with other receptor proteins not directly related to the ECS, such as the serotonin receptor 5-HT1A and vanilloid receptor TRPV1. The widely perceived anti-inflammatory and pain relieving properties of CBD could stem from the activation of these additional biological pathways.
The relationship between CBD and the human body is rather complicated, but it’s a bit easier to understand how this cannabinoid moves through the body, as well as how long it takes CBD to leave your system. Even this answer, however, is contingent on several factors, including the method of consumption, the quality of the CBD product, and the person consuming CBD.
The method of consumption matters
Method of consumption plays a critical role in how long it will take to feel the effects of CBD. CBD is available in many different forms, and each has an influence on the onset time, among other factors.
The most common method for CBD consumption involves administering a couple of drops directly into the mouth. It is the quickest and easiest way to reap the potential benefits of this cannabinoid. But quickly swallowing the oil also prevents CBD from immediately entering the bloodstream, sending it instead through the digestive tract and eventually on to the liver, where it is broken down before finally reaching the bloodstream.
Studies show that when CBD compounds are metabolized by the liver, it undergoes what is called the “first pass effect,” where enzymes in the liver reduce CBD concentration before the remainder is finally sent to the bloodstream to be circulated throughout the body.
Administering a couple of drops of CBD oil directly into the mouth is the quickest and easiest way to reap the benefits Photo by: Gina Coleman/Weedmaps
For ingestion of CBD edibles, the same principle applies. Let’s say, for example, you’re taking CBD gummies or adding a few drops of CBD oil into your favorite recipe. It will ultimately go through the same lengthy process and reduce the total CBD concentration found in your blood stream. With ingestion, it could be one to two hours before the effects of CBD finally set in.
CBD oil can be consumed sublingually by placing a few drops of CBD under the tongue before swallowing. By using this method, CBD is absorbed by the mucous membranes located in the mouth, bypassing the digestive system and liver. Compared with ingestion, this process allows the consumer to skip over the initial metabolization process, where CBD molecules are broken down in the liver, allowing it to enter the bloodstream more quickly.
Whether you’re smoking a high-CBD strain or taking a draw from a CBD vape pen, inhalation is often seen as an effective method of delivery for CBD because of how quickly it’s absorbed in the body. When CBD is smoked or vaped, cannabinoids are sent directly to the lungs, where they are rapidly absorbed into the bloodstream and put into circulation throughout the body. It reaches peak concentrations within three minutes after consumption, meaning the effects can be felt shortly after use.
Topical CBD is applied directly to the skin and can be absorbed through the surface of the skin to interact with localized cannabinoid receptors. In some cases, CBD-infused topicals should be applied liberally to overcome the low cannabinoid absorption rate of the skin. When CBD is applied topically, the effect peaks at about 90 minutes. This method of administration is often used for chronic pain in specific areas.
Topical CBD is applied directly to and can be absorbed through the surface of the skin. Photo by: Gina Coleman/Weedmaps
The way CBD operates throughout the body – and is inevitably excreted from the body – also depends on several factors that vary from person to person.
The amount of body fat influences the amount of CBD needed to be effective. Someone with a larger body mass will require more CBD in order to feel the effects. Body weight and mass also affect how long CBD remains in the system. Like THC, CBD is stored in fat cells and gradually eliminated from the body through urine and feces. Does CBD have to build up in your system to work effectively? No, but it does get stored in the fat cells and can remain in the body well after the effects of CBD diminish.
The metabolic rate of the individual also has some sway over how long CBD stays in the system. The body’s metabolism determines how long it takes to break down and synthesize compounds, which affects how long it takes the body to process and metabolize the cannabinoid.
The body’s metabolism affects how long it takes to process and metabolize cannabinoids. Photo by: Gina Coleman/Weedmaps
Frequency of use
It’s not just the human body that influences how long it takes CBD to work, but also the quality of the CBD product and how often it’s used. Once the CBD oil is acquired, the next step is to find the optimal dosing regimen, including frequency of use. Perhaps you’ve wondered to yourself:
- Should I take CBD oil in the morning or at night?
- What’s the right time of day to take CBD?
The answers will depend largely on the type of product, amount of CBD inside it, and the specific ailment you are targeting. Most reputable manufacturers will provide instructions on how to properly utilize the product, but experimentation may be required to find the optimal dose for you and your specific needs.
Settling on the ideal CBD dosage is an important part of the treatment process, and will also impact how long CBD stays in your system.
Hemp-derived CBD products are not intended to give the user a stoned buzz or intoxicated feeling, so there’s no need to be conservative with the dosage amount. Still, it’s recommended to start with a lower dosage and gradually increase it until the ideal effects are discovered.
How long does it take CBD to get out of your system?
We’ve covered the factors that determine how long it takes for CBD to work, but what about how long it takes to get CBD out of your system? Again, it depends on many of the aforementioned factors that determine the effectiveness of the cannabinoid itself.
A 2007 study states that CBD can be detected up to 72 hours after smoking. Since the effects of CBD may be felt directly after inhalation, this method is appealing for those seeking immediate pain relief. In another study, volunteers were given soft-gelatin capsules of cannabis extract containing 2.5 milligrams of THC and 1.35 milligrams of CBD. The research team found that CBD was only detectable in the blood for up to six hours after ingestion.
CBD can be detected up to 72 hours after smoking. Photo by: Gina Coleman/Weedmaps
Some people may be apprehensive to try CBD over concerns that it could cause them to fail a drug test. It’s highly unlikely that CBD would show up on most drug screenings, as most tests specifically look for the presence of THC and THC metabolites. But even hemp-derived CBD can contain trace amounts of THC, so there’s technically a chance, albeit extremely slim, of receiving a false positive test result from taking an unusually large dose (estimates range from 1,000 to 2,000 milligrams per day) of CBD oil.
For those worried about THC showing up in their system, look for broad-spectrum oil or products that contain pure CBD isolate. Broad-spectrum oil, as opposed to full spectrum oil, is refined to exclude the trace amounts of THC that may have been present in the hemp plant. Products with CBD isolate contain no THC or other plant-based cannabinoids. To find high-quality CBD, search for products that come with a certificate of analysis from a third-party testing lab to ensure that the information listed on the product label is accurate. Also, be on the lookout for products that claim to be hemp seed oil or hemp oil, which seldom contains any CBD at all.
How long does it take CBD to work? Copy article link to clipboard. Link copied to clipboard. Contents How does CBD interact with the body? The method of consumption matters
How Long Does It Take CBD to Work, Anyways?
One of the biggies: How long does it take for CBD oil to work? Because who hasn’t been in the situation where it seems like one person takes CBD and turns into a zen mother earth goddess right away, while you’re sitting over here waiting for something (anything!) to happen to take your morning anxiety away. (What’s that saying? A watched mug of CBD coffee never kicks in?)
Turns out, CBD isn’t one-size-fits-all. Various factors—such as the amount you take, the form you take it in, and where you got your CBD from—can all impact how long it takes to work, says Brooke Alpert, RD, the founder of Daily Habit, a line of CBD powder.
For example, if you’re putting your CBD product in a coffee that has almond milk or sugar or anything else that might need to be digested, your CBD will kick in more slowly than it would if you put a few drops directly under your tongue. “I look at it the same way I talk to people about their sugar consumption,” Alpert explains. “If you have juice or put a little bit on your tongue, it’s going to be an immediate reaction versus when it’s in fruit where you have fiber, which slows down absorption.” (Generally speaking, CBD oil added to a coffee or smoothie will probably take around 30 minutes before you start to feel anything.)
It’s worth noting that the research on taking CBD sublingually (science-speak for under your tongue) is mixed: As Well + Good has previously reported, many studies on the subject have included both CBD and THC, so it’s hard to generalize the findings to products that are just CBD-based. However, chemist Jesse Kater previously told tell Well+Good that “most of the literature supports the notion that CBD has better bioavailability when consumed sublingually versus orally.” That supports anecdotal evidence that CBD starts working almost immediately when taken under the tongue. Alpert agrees to an extent, saying that it can take anywhere from 10 minutes to an hour to kick in when taken sublingually.
Charlotte’s Web co-founder Jesse Stanley adds that CBD products often come in different strengths and thus the amount of CBD that works for your bestie may not work for you. “You might need to try a few strengths until you find what works for you,” he says. (Good to know!)
“Every day consistency is key,” he adds. “Rome wasn’t built in a day.” He encourages people to think of CBD as a dietary supplement and notes that it can take up to four to six weeks to “fully realize the benefits of CBD,” especially if you’re taking it to alleviate anxiety, pain, or for stress relief. “We are all unique in our needs and bodily systems. Some people experience rapid and very noticeable benefits while others notice benefits over time and daily use, which is common for many dietary supplements,” Stanley says.
The most important factor, Alpert says, is quality. There is so much variance among CBD products, and that can also impact how long it takes before you start feeling any effects. “This is where people are getting frustrated with CBD, because they’re like, ‘Well, I got a CBD gummy from my local bodega and I didn’t feel anything,’” Alpert says. Some things Alpert and Stanley say you should consider when shopping for any CBD product:
- The origin of the hemp: ”Hemp is a powerful phytoremediation crop, which means it cleans the soil, so you’ll want to find out that it’s grown using responsible farming practices in soil that is pre-tested for toxins or heavy metals,” Stanley says.
- Is the product full-spectrum? Both Stanley and Alpert recommend looking for full-spectrum products, which means that all the different compounds in the hemp—the foundation of every CBD product—work together to “further heighten [your] body’s response to CBD,” according to Stanley.
- Transparency: Look for third-party testing that shows you what’s in there, Alpert recommends. “All CBD is not created equally and it’s really important that whatever you’re buying actually has what it needs to have in order for it to be effective.” Reputable companies shouldn’t hide or obscure that info in any way.
The reality: Trial and error is the name of the game when it comes to finding the correct amount CBD that will actually work for you. With a little research, you’ll hopefully find the right amount for you that gives you the results you’re aiming for.
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Curious about how long does it take for CBD oil to work? Experts weigh in on what can affect CBD absorption and make the oil take longer to kick in.