How long does it take CBD to work?
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- How does CBD interact with the body?
- The method of consumption matters
- Dosage matters
- How long does it take CBD to get out of your system?
So, you’ve heard about cannabidiol (CBD) oil possibly working wonders for chronic pain relief, anxiety, and many other conditions. You finally sit down, unscrew the cap from the CBD oil bottle, and prepare to set out on a soothing journey guided by this non-intoxicating cannabinoid. After taking a few drops of CBD oil or applying a CBD-infused topical to the skin, you might start to ponder the following questions:
- How long does it take for CBD to work?
- How long will the effects of CBD oil last?
More clinical research is required to answer these questions with unwavering confidence, but we can still look at how CBD interacts with the body to come up with well-educated estimates.
How does CBD interact with the body?
CBD interacts with the brain and body through a number of different mechanisms, creating a complex relationship that still merits further research before we can fully understand how this cannabinoid might relieve certain ailments.
Upon entering the system CBD interacts with a wide range of proteins in the body and central nervous system. A key part of this interaction takes place within the endocannabinoid system (ECS), specifically the CB1 and CB2 cannabinoid receptors. Unlike THC, which is the intoxicating cannabinoid that binds to these receptors and creates the stoned effect, CBD actually has an inverse effect. When cannabidiol is introduced to the ECS, it inhibits the absorption of anandamide, a natural cannabinoid that regulates pain.
When cannabidiol is introduced to the endocannabinoid system, it inhibits the absorption of anandamide, a natural cannabinoid molecule that regulates pain. Photo by: Gina Coleman/Weedmaps
CBD also interacts with other receptor proteins not directly related to the ECS, such as the serotonin receptor 5-HT1A and vanilloid receptor TRPV1. The widely perceived anti-inflammatory and pain relieving properties of CBD could stem from the activation of these additional biological pathways.
The relationship between CBD and the human body is rather complicated, but it’s a bit easier to understand how this cannabinoid moves through the body, as well as how long it takes CBD to leave your system. Even this answer, however, is contingent on several factors, including the method of consumption, the quality of the CBD product, and the person consuming CBD.
The method of consumption matters
Method of consumption plays a critical role in how long it will take to feel the effects of CBD. CBD is available in many different forms, and each has an influence on the onset time, among other factors.
The most common method for CBD consumption involves administering a couple of drops directly into the mouth. It is the quickest and easiest way to reap the potential benefits of this cannabinoid. But quickly swallowing the oil also prevents CBD from immediately entering the bloodstream, sending it instead through the digestive tract and eventually on to the liver, where it is broken down before finally reaching the bloodstream.
Studies show that when CBD compounds are metabolized by the liver, it undergoes what is called the “first pass effect,” where enzymes in the liver reduce CBD concentration before the remainder is finally sent to the bloodstream to be circulated throughout the body.
Administering a couple of drops of CBD oil directly into the mouth is the quickest and easiest way to reap the benefits Photo by: Gina Coleman/Weedmaps
For ingestion of CBD edibles, the same principle applies. Let’s say, for example, you’re taking CBD gummies or adding a few drops of CBD oil into your favorite recipe. It will ultimately go through the same lengthy process and reduce the total CBD concentration found in your blood stream. With ingestion, it could be one to two hours before the effects of CBD finally set in.
CBD oil can be consumed sublingually by placing a few drops of CBD under the tongue before swallowing. By using this method, CBD is absorbed by the mucous membranes located in the mouth, bypassing the digestive system and liver. Compared with ingestion, this process allows the consumer to skip over the initial metabolization process, where CBD molecules are broken down in the liver, allowing it to enter the bloodstream more quickly.
Whether you’re smoking a high-CBD strain or taking a draw from a CBD vape pen, inhalation is often seen as an effective method of delivery for CBD because of how quickly it’s absorbed in the body. When CBD is smoked or vaped, cannabinoids are sent directly to the lungs, where they are rapidly absorbed into the bloodstream and put into circulation throughout the body. It reaches peak concentrations within three minutes after consumption, meaning the effects can be felt shortly after use.
Topical CBD is applied directly to the skin and can be absorbed through the surface of the skin to interact with localized cannabinoid receptors. In some cases, CBD-infused topicals should be applied liberally to overcome the low cannabinoid absorption rate of the skin. When CBD is applied topically, the effect peaks at about 90 minutes. This method of administration is often used for chronic pain in specific areas.
Topical CBD is applied directly to and can be absorbed through the surface of the skin. Photo by: Gina Coleman/Weedmaps
The way CBD operates throughout the body – and is inevitably excreted from the body – also depends on several factors that vary from person to person.
The amount of body fat influences the amount of CBD needed to be effective. Someone with a larger body mass will require more CBD in order to feel the effects. Body weight and mass also affect how long CBD remains in the system. Like THC, CBD is stored in fat cells and gradually eliminated from the body through urine and feces. Does CBD have to build up in your system to work effectively? No, but it does get stored in the fat cells and can remain in the body well after the effects of CBD diminish.
The metabolic rate of the individual also has some sway over how long CBD stays in the system. The body’s metabolism determines how long it takes to break down and synthesize compounds, which affects how long it takes the body to process and metabolize the cannabinoid.
The body’s metabolism affects how long it takes to process and metabolize cannabinoids. Photo by: Gina Coleman/Weedmaps
Frequency of use
It’s not just the human body that influences how long it takes CBD to work, but also the quality of the CBD product and how often it’s used. Once the CBD oil is acquired, the next step is to find the optimal dosing regimen, including frequency of use. Perhaps you’ve wondered to yourself:
- Should I take CBD oil in the morning or at night?
- What’s the right time of day to take CBD?
The answers will depend largely on the type of product, amount of CBD inside it, and the specific ailment you are targeting. Most reputable manufacturers will provide instructions on how to properly utilize the product, but experimentation may be required to find the optimal dose for you and your specific needs.
Settling on the ideal CBD dosage is an important part of the treatment process, and will also impact how long CBD stays in your system.
Hemp-derived CBD products are not intended to give the user a stoned buzz or intoxicated feeling, so there’s no need to be conservative with the dosage amount. Still, it’s recommended to start with a lower dosage and gradually increase it until the ideal effects are discovered.
How long does it take CBD to get out of your system?
We’ve covered the factors that determine how long it takes for CBD to work, but what about how long it takes to get CBD out of your system? Again, it depends on many of the aforementioned factors that determine the effectiveness of the cannabinoid itself.
A 2007 study states that CBD can be detected up to 72 hours after smoking. Since the effects of CBD may be felt directly after inhalation, this method is appealing for those seeking immediate pain relief. In another study, volunteers were given soft-gelatin capsules of cannabis extract containing 2.5 milligrams of THC and 1.35 milligrams of CBD. The research team found that CBD was only detectable in the blood for up to six hours after ingestion.
CBD can be detected up to 72 hours after smoking. Photo by: Gina Coleman/Weedmaps
Some people may be apprehensive to try CBD over concerns that it could cause them to fail a drug test. It’s highly unlikely that CBD would show up on most drug screenings, as most tests specifically look for the presence of THC and THC metabolites. But even hemp-derived CBD can contain trace amounts of THC, so there’s technically a chance, albeit extremely slim, of receiving a false positive test result from taking an unusually large dose (estimates range from 1,000 to 2,000 milligrams per day) of CBD oil.
For those worried about THC showing up in their system, look for broad-spectrum oil or products that contain pure CBD isolate. Broad-spectrum oil, as opposed to full spectrum oil, is refined to exclude the trace amounts of THC that may have been present in the hemp plant. Products with CBD isolate contain no THC or other plant-based cannabinoids. To find high-quality CBD, search for products that come with a certificate of analysis from a third-party testing lab to ensure that the information listed on the product label is accurate. Also, be on the lookout for products that claim to be hemp seed oil or hemp oil, which seldom contains any CBD at all.
How long does it take CBD to work? Copy article link to clipboard. Link copied to clipboard. Contents How does CBD interact with the body? The method of consumption matters
CBD Oil Dosage: General Tips to Assess How Much CBD to Take
Written by Jason Brett — Edited by on March 15, 2021
By and large, the acceptance and use of cannabidiol as a therapeutic, healing substance is in its infancy. Medical professionals and scientists are only now beginning to develop dosing schedules for medical marijuana, medicinal hemp, and their extracts (including CBD).
Even with the current wave of states legalizing medical marijuana, many physicians are hesitant to prescribe cannabinoids like CBD. This is for two reasons:
1 – Doctors cannot prescribe (only recommend) cannabinoids, because there’s no recommended daily allowance (RDA) or universal dose for all people.
2 – Most medical schools never cover CBD/cannabidiol therapy in their pharmacology courses (the drug curriculum revolves primarily around substances that can be patented).
Because there is no recommended dose, the information presented on this page is intended to serve only as an informational guide – a starting point of reference – and should never be considered medical advice.
When it comes to cannabinoids, there is one universal truth to keep in mind:
Everyone Is Different
While we wish we could provide the public with a mathematical CBD dosage calculator, it isn’t quite that simple – very rough estimates are about as good as it gets.
With these facts in mind, most people who are new to cannabidiol begin their journey by starting with the minimal suggested CBD dosage on any product, then gradually increasing the dose until they achieve the desired results.
We at CBD Oil Review (COR) have created an official COR Serving Standard through an extensive analysis of hundreds of CBD products .
The (COR) Serving Standard is 25mg of CBD, taken twice daily.
Additionally, our analysis suggests increasing the amount of CBD you take every 3-4 weeks by 25mg until you attain symptom relief (inversely, decrease by 25mg if symptoms worsen).
Additionally, you might find it useful to record your daily experiences in a notebook so you can accurately narrow in on what works and feels best for you. With that understanding in place, it is now time to learn more about CBD oil and how to find the right CBD oil dosage for you.
How Much CBD Oil Should I Take?
Mayo Clinic suggests CBD dosages based on scientific research, publications, traditional use, and expert opinion. Cannabinoid dosages and duration of treatment depend mainly on the illness (and countless other factors).
The Mayo Clinic provides specific dosage recommendations for various illnesses, including:
- Loss of Appetite in Cancer Patients: 2.5mg of THC (orally), with or without 1mg of CBD for six weeks. [ S ]
- Pain Relief: 100-150mg of CBD, or 25mg when combined with THC.[ S , S , S ]
- Epilepsy: A daily dose of 20 – 25mg of CBD per Kg bodyweight. [ S , S ]
- Movement Problems Due to Huntington’s Disease: 10mg of CBD per kg of body weight daily for six weeks (orally). [ S ]
- Sleep Disorders: 40mg-160mg of CBD (orally). [ S ]
- Multiple Sclerosis (MS) symptoms: Cannabis plant extracts containing 2.5-120 milligrams of a THC/CBD combination daily for 2-15 weeks. Patients typically use eight sprays within any three hours, with a maximum of 48 sprays in any 24-hour period. [ S ]
- Schizophrenia: 40-1,280mg oral CBD daily. [ S ]
Learn the Types of CBD Products
CBD hemp oil comes in seemingly endless forms, each with a different concentration of CBD and other phytocannabinoids. Determining how to use CBD oil first starts with choosing your route of administration – in other words, choosing the best way to take CBD oil for your needs and lifestyle.
- Liquid hemp oil, like CBD tinctures or CBD drops
- CBD concentrated into a thick paste (often referred to as Rick Simpson Oil, or RSO)
- Encapsulated CBD oil
- Phytocannabinoid-rich sprays/spritzers (generally designed for application beneath the tongue)
- Bottled water containing nano-sized CBD particles
- CBD-infused chewing gum
- On-the-go dissolvable powders containing CBD (oftentimes blended with other adaptogenic herbs)
- Cooking oils (such as coconut oil or olive oil) with added cannabinoids
- CBD-infused edibles (i.e., gummies, brownies, cookies, etc.; generally for individuals who are sensitive to smoking/vaping)
- Crystalline isolates
- Wax (similar to THC-containing marijuana concentrates called “shatter”)
- CBD-rich eLiquids and/or vape cartridges (akin to an e-cigarette)
- Transdermal patches with CBD (similar to a nicotine patch)
- Cannabidiol-infused salves,balms, lotions, shampoos, or soaps (for topical use)
- Bath bombs infused with CBD
Decide How to Use CBD Oil
While many options like chewing gum need no instructions, we have compiled these tips on how to take CBD oil:
Liquid CBD Oil/Tinctures/Extracts: Drops or tinctures should have a “suggested serving size” and the total milligrams of CBD listed on their packaging. From there, you can determine the amount of CBD you would like to ingest. Simply place the correct quantity of drops under your tongue using the dropper and hold the CBD oil in place for a minimum of 60 seconds. The 60 second hold allows for absorption via the blood vessels underneath your tongue – efficiently bypassing first-pass metabolism. Once 60 seconds has passed, swallow the CBD oil.
CBD E-Liquid/Vape Cartridges: Vaping is excellent for people looking for an immediate response, as inhalation is the fastest way to deliver CBDs to your brain and body. To use vape simply exhale gently the air from your lungs then inhale through the mouthpiece slowly for 3 seconds. Then fill your lungs the rest of the way with additional breath and hold for a few seconds, exhaling when ready. There are pre-filled, cost-effective vape pens and cartridges available as well as more expensive vaporizers that you can refill with CBD-infused e-liquid.
CBD Edibles: With edibles, the only required steps are open, eat, and enjoy! This method of consumption will result in more drawn-out effects that also take longer to kick in than some of the other options. Edibles are great for those seeking sustained effects, or for those who want to be subtle about their usage of CBDs.
CBD Isolates/Concentrates: Anyone familiar with smoking hash or other cannabis concentrates like wax and BHO will be no stranger to this delivery method. Simply sprinkle some into a vaporizer or water pipe, ignite, inhale, and enjoy! We find that this option is useful for individuals looking to elevate their regular consumption of CBD-rich cannabis flowers or other smokable herbs.
For quick reference, refer to this chart of ingestion methods for the pros and cons of each delivery method so can decide for yourself the best way to take CBD oil:
|Delivery Method||Pros||Cons||Time of Onset||Duration of Effects||Recommended if you…|
|Ingestibles (E.g. edibles; capsules; oil drops; drink powders)||Convenient; Dosage control; Discreet; Familiar; Doesn’t harm the lungs||Slow to take effect||30-60 minutes||Edibles/Capsules:4-6 hours; Tinctures/Drops: 2-4 hours||Consider discretion a top priority and/or want more control over dosage|
|Smokables (E.g. Vapes; flower)||Fast acting; Easy to use; Social; Familiar||Non-discreet; Smoking/Vaping are illegal in many public settings; Can feel harsh on the lungs||Instant||45 minutes-1 hour||Are trying to quit cigarettes or need fast-acting relief|
|Topicals (E.g. Lotions; balms; gels)||Can be applied directly to affected area; Bypasses liver metabolism; Long-lasting; Can be worked into daily hygiene routine||Slow to take effect||Varies widely due to factors like hair growth and amount of fatty tissue||Typically 5+ hours||Experiencing local pain of the skin or joints or into body care in general.|
|Transdermal Patches||Longest lasting effects;Bypasses liver metabolism;Steady release of CBD into the bloodstream||May take hours to feel effects||Varies depending on amount of fatty tissue and hair on the skin||1-2 days||Have chronic pain or will go a long period of time where the other delivery methods aren’t available|
Choose a CBD Brand with a Dosage You Can Trust
Figuring out how much CBD oil to take can feel like trying to navigate through a complicated maze. The sheer volume of CBD brands on the market can create confusion for consumers, and when you take a closer look, it’s not difficult to understand why. Not only do vendors use different source materials (CBD-rich cannabis vs. industrial hemp, different strains, etc.), but they also implement different extraction techniques .
Adding to the confusion, many vendors recommend excessive doses, while others suggest amounts that are a fraction of what experts would consider effective.
As with a fermented food like kombucha, slight natural variations are normal and to be expected in a product such as CBD oil because it is made from living plants. Changes in the weather, soil, and water can all impact the biology of the source material. While we verify Certificates of Analysis (and take many other criteria into consideration during our review process), even the most reputable five-star companies have no way to control for every variable in this organic process.
While perhaps not as ideal as a CBD dosage chart, we at CBD Oil Review (COR) have created an official COR Serving Standard through an extensive analysis of hundreds of products.
The (COR) Serving Standard is 25mg of CBD, taken twice daily.
Additionally, our analysis suggests increasing the amount of CBD you take every 3-4 weeks by 25mg until you attain symptom relief (inversely, decrease by 25mg if symptoms worsen).
Consider Why Your Health Would Benefit from CBD
Cannabinoids such as CBD have a dizzying array of functions in the human body, influencing everything from inflammation to anxiety and depression. You don’t necessarily need to have a serious illness to benefit from CBD; even healthy individuals can experience a remarkable increase in their quality of life with its use.
The following is a chart of illnesses/conditions that whose symptoms may be relieved by CBD:
Keep in mind that this CBD benefits list is in no way complete; we are only beginning to discover how cannabinoids can help.
Know You Cannot Overdose on CBD
There is no established lethal dose of CBD, and chronic use/high doses of up to 1500 mg per day ( 30x MORE than the COR Serving Standard!) have been repeatedly shown to be well tolerated by humans.
As with any natural product, it is important to speak with your physician prior to beginning use. There are some slight risks associated with using CBD in high doses or for extended periods of time, including:
- Mild Low Blood Pressure
- Dry Mouth
- Reduced activity of T and B Cells
- Decreased Fertilization Capacity
- Reduced p-Glycoprotein activity
- Reduced activity of Cytochrome P450 (CYP450) Enzyme
Keep in mind that these side effects illustrate worst-case scenarios with CBD, and are not necessarily typical.
There is one major exception to the “generally harmless” attitude about CBD and that is the negative effect cannabinoids can have on the functioning of the liver’s CYP450 enzyme . Approximately 60% of all pharmaceutical drugs are degraded by this enzyme, and CBD can slow the metabolization of these drugs:
- HMG CoA reductase inhibitors
- Calcium channel blockers
- Immune modulators
- Beta blockers
- Angiotensin II blockers
- Oral hypoglycemic agents
Before you start taking CBD, please read about drug interactions .
It is important to note that even something as benign as grapefruit juice can cause the same CYP450 enzyme inhibitory action as CBD.
The most important things to do before taking CBD (or any other herbal product) are research any possible drug interactions and talk with your physician to address any additional questions regarding CBD drug interactions or overdose concerns. You and your doctor together will always know best!
Understand How Your Genetics Impact CBD Dosing
As if you didn’t have enough factors to consider when deciding your ideal CBD oil dosage, now you have to think about how your own genetics can impact this amount.
Some individuals have been found to have mutations on the CNR1 gene, which is responsible for coding the CB1 receptor (a type of receptor in cells throughout your body that interacts with cannabinoids). Issues with the CNR1 gene can ultimately result in a poorly functioning endocannabinoid system , which is an important variable when figuring out how to use CBD oil.
How lifestyle choices impact the effect of CBD
Various substances can profoundly affect CB1 receptors. Certain lifestyle choices can impact how your body metabolizes CBD.
We are only beginning to understand which factors influence CBD metabolism, and as such it’s a good idea to take anything related to this emerging science with a grain of salt. As with any natural substance, consult with your physician about any questions and/or concerns you may have regarding CBD and how to use CBD oil.
Rest Easy Knowing CBD Oil Is Not Physically Addictive
People often ask us, “ Can I get addicted to CBD oil ?” This is a tricky question, and the answer ultimately depends on your school of thought.
Based strictly on chemistry, the answer is no. Cannabidiol is not physically addictive in the same way substances like heroin, cocaine, alcohol, opiates, benzodiazepines, and related substances can be. Further, CBD cannot produce any physical withdrawal symptoms in and of itself upon cessation of use.
(Interestingly, CBD is currently undergoing study for its ability to minimize withdrawal from drugs with severe cessation symptoms, like opiates.)
However, human beings can get addicted to just about anything that isn’t chemically addicting: exercise, music, sex, and food are great examples.
Those who take CBD daily to relieve symptoms of chronic illness and other severe conditions may find that their unpleasant sensations return shortly after they miss a dose. This is no different than one’s headache returning once the effects of ibuprofen wear off.
However, because CBD can alter the levels of essential liver enzymes , it is crucial to do your research, talk to your physician, and figure out the best way to take CBD oil for your specific situation. Information and education will be your allies in your quest for healing.
Get the Most Bang for Your Buck
If you’ve been using CBD products for some time without verifying the potency through their vendors, it’s highly probable you’ve been using a minimally effective formulation that hasn’t been delivering as much CBD as you thought (or as much as you’ve paid for!).
This is why CBD Oil Review exists, why we’ve created our five-badge rating system, and why we’ve enlisted independent reviewers to verify that CBD companies are being ethical.
Becoming a CBD Oil Review member not only supports our mission, but members also get new deals on five-star brands only , delivered directly to their inbox. If you are looking for which brands to trust or which products to purchase, take a look at our buyers guides here:
Consider a Cannabis Doctor to Answer Your Difficult Questions
Most doctors don’t specialize medicinal cannabis and CBD oil. This means they may not be able to help you as thoroughly as you had hoped and they may be unable to offer guidance when it comes to helping you decide how much CBD oil to take. It is also worth noting that many patients feel uncomfortable talking to their doctor about cannabis and CBD.
If you have detailed questions about how much CBD oil to take, how to take CBD oil, drug interactions, or just want to know what to do next, consult with a cannabis doctor today!
CBD oil dosage depends largely on the disease. Everyones dosage needs are different, it is best to start with a small CBD dose and increase slowly…