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how to use cbd oil for crohn’s disease

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What is Crohn’s disease?

Crohn’s disease is a long-term condition that results in inflammation of the gastrointestinal tract, occurring anywhere from the mouth to the anus. Common symptoms include fever, diarrhoea, abdominal pain and weight loss. Crohn’s disease is characterized by periods of relapse when people are actively experiencing symptoms and periods of remission when the symptoms stop.

What are Cannabis and Cannabinoids?

Cannabis is a widely used drug which acts on the endocannabinoid system. Cannabis contains multiple components called cannabinoids. The use of cannabis and cannabis oil containing specific cannabinoids produces mental and physical effects such as altered sensory perception and euphoria when consumed. Some cannabinoids, such as cannabidiol, do not have a psychoactive effect. Cannabis and cannabidiol have some anti-inflammatory properties that might help people with Crohn’s disease.

What did the researchers investigate?

The researchers studied whether cannabis is better than placebo (e.g. a sugar pill) therapy for treating adults with active Crohn’s disease or Crohn’s disease that is in remission.

What did the researchers find?

The researchers extensively searched the literature up to 17 October 2018 and found three studies (93 participants) that met the inclusion criteria. One ongoing study was also identified. All of the studies were small in size and had some quality issues. One small study (21 participants) compared eight weeks of treatment with cannabis cigarettes containing 115 mg of D9-tetrahydrocannabinol (THC) to placebo cigarettes containing cannabis with the THC removed in participants with active Crohn’s disease who had failed at least one medical treatment. Although no difference in clinical remission rates was observed, more participants in the cannabis group had improvement in their Crohn’s disease symptoms than participants in the placebo group. More side effects were observed in the cannabis cigarette group compared to placebo. These side effects were considered to be mild in nature and included sleepiness, nausea, difficulty with concentration, memory loss, confusion and dizziness. Participants in the cannabis cigarette group reported improvements in pain, appetite and satisfaction with treatment.

One small study (22 participants) compared cannabis oil (10 mg of cannabidiol twice daily) to placebo oil (i.e. olive oil) in participants with active Crohn’s disease who had failed at least one medical treatment. No difference in clinical remission rates was observed. There was no difference in serious side effects. Serious side effects included worsening Crohn’s disease in one participant in each group.

One small study (50 participants) compared cannabis oil (composed of 15% cannabidiol and 4% THC) to placebo oil in participants with active Crohn’s disease. Positive differences in quality of life and the Crohn’s disease activity index were observed.

Conclusions

The effects of cannabis and cannabis oil on Crohn’s disease are uncertain. No firm conclusions regarding the benefits and harms (e.g. side effects) of cannabis and cannabis oil in adults with Crohn’s disease can be drawn. The effects of cannabis and cannabis oil in people with Crohn’s disease in remission have not been investigated. Further studies with larger numbers of participants are required to assess the potential benefits and harms of cannabis in Crohn’s disease. Future studies should assess the effects of cannabis in people with active and inactive Crohn’s disease. Different doses of cannabis and formulations (e.g. cannabis oil or pills) should be investigated.

The effects of cannabis and cannabis oil on Crohn’s disease are uncertain. Thus no firm conclusions regarding the efficacy and safety of cannabis and cannabis oil in adults with active Crohn’s disease can be drawn. The effects of cannabis or cannabis oil in quiescent Crohn’s disease have not been investigated. Further studies with larger numbers of participants are required to assess the potential benefits and harms of cannabis in Crohn’s disease. Future studies should assess the effects of cannabis in people with active and quiescent Crohn’s disease. Different doses of cannabis and delivery modalities should be investigated.

Crohn’s disease (CD) is a chronic immune-mediated condition of transmural inflammation in the gastrointestinal tract, associated with significant morbidity and decreased quality of life. The endocannabinoid system provides a potential therapeutic target for cannabis and cannabinoids and animal models have shown benefit in decreasing inflammation. However, there is also evidence to suggest transient adverse events such as weakness, dizziness and diarrhea, and an increased risk of surgery in people with CD who use cannabis.

The objectives were to assess the efficacy and safety of cannabis and cannabinoids for induction and maintenance of remission in people with CD.

We searched MEDLINE, Embase, AMED, PsychINFO, the Cochrane IBD Group Specialized Register, CENTRAL, ClinicalTrials.Gov, and the European Clinical Trials Register up to 17 October 2018. We searched conference abstracts, references and we also contacted researchers in this field for upcoming publications.

Randomized controlled trials comparing any form of cannabis or its cannabinoid derivatives (natural or synthetic) to placebo or an active therapy for adults with Crohn’s disease were included.

Two authors independently screened search results, extracted data and assessed bias using the Cochrane risk of bias tool. The primary outcomes were clinical remission and relapse. Remission is commonly defined as a Crohn’s disease activity index (CDAI) of 150. Secondary outcomes included clinical response, endoscopic remission, endoscopic improvement, histological improvement, quality of life, C-reactive protein (CRP) and fecal calprotectin measurements, adverse events (AEs), serious AEs, withdrawal due to AEs, and cannabis dependence and withdrawal effects. We calculated the risk ratio (RR) and corresponding 95% confidence interval (95% CI) for dichotomous outcomes. For continuous outcomes, we calculated the mean difference (MD) and 95% CI. Data were combined for analysis when the interventions, patient groups and outcomes were sufficiently similar (determined by consensus). Data were analyzed on an intention-to-treat basis and the overall certainty of the evidence supporting the outcomes was evaluated using the GRADE criteria.

Three studies (93 participants) that assessed cannabis in people with active CD met the inclusion criteria. One ongoing study was also identified. Participants in two of the studies were adults with active Crohn’s disease who had failed at least one medical treatment. The inclusion criteria for the third study were unclear. No studies that assessed cannabis therapy in quiescent CD were identified. The studies were not pooled due to differences in the interventional drug.

One small study (N = 21) compared eight weeks of treatment with cannabis cigarettes containing 115 mg of D9-tetrahydrocannabinol (THC) to placebo cigarettes containing cannabis with the THC removed in participants with active CD. This study was rated as high risk of bias for blinding and other bias (cannabis participants were older than placebo). The effects of cannabis on clinical remission were unclear. Forty-five per cent (5/11) of the cannabis group achieved clinical remission compared with 10% (1/10) of the placebo group (RR 4.55, 95% CI 0.63 to 32.56; very low certainty evidence). A difference was observed in clinical response (decrease in CDAI score of >100 points) rates. Ninety-one per cent (10/11) of the cannabis group achieved a clinical response compared to 40% (4/10) of the placebo group (RR 2.27, 95% CI 1.04 to 4.97; very low certainty evidence). More AEs were observed in the cannabis cigarette group compared to placebo (RR 4.09, 95% CI 1.15 to 14.57; very low certainty evidence). These AEs were considered to be mild in nature and included sleepiness, nausea, difficulty with concentration, memory loss, confusion and dizziness. This study did not report on serious AEs or withdrawal due to AEs.

One small study (N = 22) compared cannabis oil (5% cannabidiol) to placebo oil in people with active CD. This study was rated as high risk of bias for other bias (cannabis participants were more likely than placebo participants to be smokers). There was no difference in clinical remission rates. Forty per cent (4/10) of cannabis oil participants achieved remission at 8 weeks compared to 33% (3/9) of the placebo participants (RR 1.20, 95% CI 0.36 to 3.97; very low certainty evidence). There was no difference in the proportion of participants who had a serious adverse event. Ten per cent (1/10) of participants in the cannabis oil group had a serious adverse event compared to 11% (1/9) of placebo participants (RR 0.90, 95% CI 0.07 to 12.38, very low certainty evidence). Both serious AEs were worsening Crohn’s disease that required rescue intervention. This study did not report on clinical response, CRP, quality of life or withdrawal due to AEs.

One small study (N= 50) compared cannabis oil (15% cannabidiol and 4% THC) to placebo in participants with active CD. This study was rated as low risk of bias. Differences in CDAI and quality of life scores measured by the SF-36 instrument were observed. The mean quality of life score after 8 weeks of treatment was 96.3 in the cannabis oil group compared to 79.9 in the placebo group (MD 16.40, 95% CI 5.72 to 27.08, low certainty evidence). After 8 weeks of treatment, the mean CDAI score was118.6 in the cannabis oil group compared to 212.6 in the placebo group (MD -94.00, 95%CI -148.86 to -39.14, low certainty evidence). This study did not report on clinical remission, clinical response, CRP or AEs.

Cochrane What is Crohn’s disease? Crohn’s disease is a long-term condition that results in inflammation of the gastrointestinal tract, occurring anywhere from the mouth to the anus. Common

Best CBD Oil For Crohn’s – Top 4 Relieving Products

cbd oil dosage for crohn

Crohn’s disease [1] is a chronic, long-term type of inflammatory bowel disease characterized by inflammation in the gastrointestinal tract. It is one of two main types of inflammatory bowel disease along with ulcerative colitis. Both conditions involve an immune reaction against the intestinal tract. Crohn’s disease symptoms [2] are unpleasant and characterized by bloody diarrhea, fever, rectal bleeding, weight loss, and abdominal pain. It is controlled by medications that target the inflammation, including antibiotics, anti-inflammatories, steroids, immune modifiers, or biologic agents. While the exact cause is not understood, it is thought that a combination of genetics, environment, or an overactive immune system may provoke the disease. CBD oil dosage for crohn’s disease is considered a potential cure.

While symptoms may come and go, the onset of symptoms is unpredictable. The treatment goal is the remission of Crohn’s disease symptoms caused by the inflammatory bowel disease process. A special diet is often followed to control the symptoms that include the elimination of alcohol and a restriction of fiber, butter, carbonated beverages, caffeine products, dairy, fatty foods, and corn. Despite the limitations, patients need to maintain a healthy diet because inflammation makes it difficult to absorb nutrients. Avoiding “trigger foods” may help alleviate the inflammatory bowel disease (IBD) symptoms of gas, bloating, and abdominal cramping.

Top 4 Best cbd oil dosage for crohn’s disease (April. 2021)

  • Spruce CBD – Editor’s choice
  • CBD Pure – Best Organic
  • Joy Organics – Best Technology
  • Medterra – Best Price

CBD Oil for Crohn’s

About 15% of inflammatory bowel (IBD) patients report [3] using cannabis to alleviate their symptoms. It appears that medical marijuana has a place in the treatment of IBD. A recent study [4] showed benefits in using 30g marijuana/month that translated into 21 mg THC and 170 mg CBD per day for each of the 173 patients followed. Cannabis decreased the need for other medications. The use of cannabis oil is reported [5] among IBD adolescent patients in another study. Their perceived health benefits from use were on sleep quality, appetite, and nausea.

In the lower digestive tract, endocannabinoids are supposed to protect the gut and reduce motility and inflammation – both of which may lead to the disabling pain associated with ulcerative colitis and Crohn’s disease. Analgesic properties [6] of cannabis products are proposed to be via the TRPV1 endocannabinoid system receptors, and relief is often sought using cannabis oils for the abdominal pain that accompanies the cramping of IBD. The anti-inflammatory effect cannabidiol (CBD) has on tissues should help decrease intestinal inflammation-associated pain. CBD has potent anti-inflammatory activities on pro-inflammatory mediators, making it an ideal choice for the treatment of people with IBD. Read on to find out the best CBD oil dosage for Crohn’s disease.

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Top 5 Best CBD Oil for Crohn’s Disease

Spruce CBD

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Spruce is a family-run CBD brand that offers high-quality, lab-tested, full-spectrum CBD oils made from one of the finest, oldest hemp strains in the United States.

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Established in 2018, Spruce is a CBD brand based in Raleigh, North Carolina. The company prides itself on making American-made CBD products and some of the best CBD oils available.

Spruce stands out from the competition in several ways. For instance, it’s a family-run business, which is unusual in the CBD industry.

Its CBD is sourced from a time-tested strain of hemp cultivated in the United States for over two hundred years. The CBD-rich oil is harvested from organically grown hemp from farms in Kentucky and North Carolina.

Spruce is also unique for using a moonshine (alcohol) extraction method to isolate a CBD-rich extract from hemp. Alcohol extraction has proven to be safe and effective.

Spruce’s CBD oils are made with lab-tested hemp extracts, and it provides all of the cannabinoids, terpenes, and other beneficial compounds found in the original plant.

It has a pleasing peppermint taste and comes in 30 ml bottles with two CBD potencies: 25 mg of CBD per ml (750 mg total) and 80 mg of CBD per ml (2400 mg total).

The company carries a wide range of products, including topicals, lotions, balms, tinctures, oils, and capsules.

Medterra

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Medterra manufactures broad-spectrum oil with entourage effects, plus its wide variety of products are all CO2 extracted to yield the best CBD oils for the money.

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Medterra is a reputable brand with various CBD products to choose from, including creams, tinctures, edibles, oils, and supplements. Their product line-up includes supplies for your pets.

Their CBD broad-spectrum tincture comes in two potencies, 1000 mg. and 2000 mg. in two flavors plus natural unflavored. CBD oil comes in 500 mg. – 3,000 mg. bottles.

CO2, the gold standard extraction method, can remove THC and impurities from the hemp seed oil to ensure quality CBD oil products.

The wide variety of CBD products all come with a detailed third-party Certificate of Analysis of potency and contaminants. Better yet, it is certified by the U.S. Hemp Authority, which issues guidelines on stringent hemp processing. Third-party testing, as for most products on this list, is conducted on all Medterra products.

MCT is added as a carrier oil and to provide fatty acids. MCT helps the body absorb cannabinoids in the products.

CBDPure

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CBDPure is a family-run business that offers organically grown hemp at an affordable price.

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This organic farm began in 2016 in Colorado with a mission to provide the best CBD products on the market. The farm does not use pesticides or herbicides on its organic ranch in Colorado or its ranch in Washington.

The company does third-party testing with the Certificate of Analysis on its products’ purity for downloading off their website. Their Certificate of Analysis outlines the presence of cannabinoids, terpenes, solvents, pesticides, microbial growth, and heavy metals.

All of their products are minimally processed and grown on family-run farms.

They are affordable and even offer coupons to help defray expenses. We can apply these coupons at check-out for all CBD products.

They offer one natural flavor in three different concentrations of full-spectrum hemp oil, 300 mg, 600 mg, and 900 mg in 30 cc bottles.

The company customer service is highly responsive, with a chat window on the website for immediate assistance if needed. They make sure to meet your requirement.

To prove confidence in their product, CBDPure offers a 100% money-back guarantee. If you are not happy with the products, return them within 90 days for a refund.

Joy Organics

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The company prides itself on its transport to all U.S. states and in its freedom from harsh metals, THC and gluten.

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Joy Organic uses only phytocannabinoid-rich hemp that contains a range of 112 cannabinoids in its oils for a rich entourage effect.. Most CBD oils have a trace of THC in them, but not Joy Organic! Full-spectrum CBD oils are also available with both CBD and less than 0.3% of THC to create the full entourage effect.

The CBD products go through a testing process whereby a Certificate of Quality Assurance and a Certificate of Analysis are generated by both in-house testing and a third-party lab. Both of these represent standards of quality.

Joy Organic prides itself on using only the finest U.S. grown hemp. Standards at American hemp farms are higher than those in other countries.

The CBD products come in four flavors, orange, tranquil, natural, and mint. The four flavors come in different potencies, 250, 500, 1000, and 1500 mg per 30 ml bottle.

The oil itself undergoes a process to make it more bioavailable, a nanotechnology

emulsion technique that involves breaking down the molecule into smaller, more digestible components.

CBD Oil Dosage for Crohn’s Disease

The dosage for Crohn’s disease has not been identified in the literature. We have gleaned that too low of a dose is ineffective at treating inflammatory bowel disease (IBD). For example, during eight weeks of treatment with 10 mg cannabidiol (CBD), no significant improvement [7] was noted in 20 patients. Researchers conclude from this study that the dose might have been too low, but they also mention that this was a CBD isolate and do not have the benefits of other cannabinoids for an entourage effect.

In a study of 127 patients undergoing treatment [7] for Crohn’s disease, the dosage used to be effective in intestinal inflammation was 170 mg of CBD in the form of medical cannabis, which also contained THC. This study points to the fact that IBD patients may need a higher dose than 10 mg to exert the necessary anti-inflammatory effects and impact functional symptoms. It also may indicate that using a CBD isolate may perform differently than full extracts from the cannabis sativa plant with all the entourage effects.

In animal models, research has shown positive effects on inflammation in the gut by rectally administering cannabidiol at a dosage of 20 mg/kg. This study indicated a possible role [8] for topical administration directly into the gut mucosa to help decrease inflammation.

In another study on rats, cannabinoids [9] that included THC, at a dose of 10 mg/kg showed a reduction in inflammation and functional symptoms. The dosage curve followed a bell-shaped pattern.

Before trying CBD for gut inflammation, one should seek medical advice, diagnosis, or treatment first as the dosage for this cannabinoid needs tailoring to the individual and drug interactions assessed before administering any dose. Involving the health care system in your decision to use CBD oil will facilitate coordination of treatment.

How Does CBD Oil Help Crohn’s Disease

Cannabinoid receptors 1 and 2, endogenous cannabinoids, and atypical cannabinoids are upregulated in inflammation [10] , and their presence and stimulation aggravate colitis. In contrast, cannabinoid receptor antagonism and cannabinoid receptor-deficient animal models reverse these anti-inflammatory effects. The endocannabinoid system is implicated [11] in gut homeostasis, regulation of intestinal motility, visceral sensation, inflammation, and being recently involved in treating IBD.

Another study demonstrated [12] a role for cannabinoids in reducing intestinal permeability and reducing inflammation and regulation of intestinal bacteria, especially as it related to alcohol use disorders. All of these factors can play a role in symptomatic flare-ups in patients with IBD.

How to Take CBD Oil for Crohn’s Disease

Many people turn to CBD with and without medical advice. Those who may not use CBD may use cannabis to control their pain, weight loss, nausea, and other side-effects of their illness. Cannabis or CBD might play a role in increasing the quality of life for patients with IBD.

You can take CBD in the form of oils, tinctures, capsules, or applied topically in the form of lotion, balms, or creams. For patients with IBD, the best way to take CBD is orally or through the bloodstream by putting tinctures or oils under the tongue or inhaling the oils’ vapors. One might achieve significant health benefits from incorporating the many CBD products on the market into their lifestyle.

Research on CBD and Crohn’s Disease

To date, most of the research has been on cannabis-related products containing a mixture of THC and CBD. The problem is, THC is not legal in every state, and not all people want the “high” effects associated with the use of such products. For this reason, hemp-extracted CBD products are being explored as a treatment option for IBD. The problem with researching CBD oil dosage for crohn’s disease is that the Food and Drug Administration has only patented one CBD drug, which was for epilepsy. It has not been approved for the treatment of this disease.

In a novel approach, a patented enema [13] (all rights reserved) formulation containing CBD has been introduced into the market. The enema protects the intestinal permeability barrier, controls diarrhea, and improves microbiome function. It was explicitly designed with IBD patients in mind after an extensive medical review of the literature.

Still, in light of all the positive data on how CBD might help people with IBD, the medical system seems reluctant to embrace its therapeutic values in health promotion and disease prevention. Many patients could achieve significant health benefits from the use of these products. However, the bottom line is, more research study is in need.

Frequently Asked Questions

Many people turn to CBD for their pain relief and to benefit their overall health. People with IBD have no guidance on dosage for their condition because the FDA has not approved it for use in treating the side-effects associated with IBD. From a review of the studies, it seems that too low of a dose is ineffective at treating symptoms such as weight loss or pain, but the bell-shaped curve present in other dosage studies indicate there might be a “sweet spot” or dosage where symptoms resolve, but a
higher or lower dose will not have the same remission effects. The best thing to ask for medical advice from your healthcare provider.

CBD might help people with IBD manage their health better by decreasing their disease’s symptoms through pain reduction and anti-inflammatory actions. However limited, studies have shown beneficial effects on IBD symptoms in both animals and humans with the use of CBD.

Chemo and Hash plant, both Indica strains, are suitable for Crohn’s disease. Lemon
Jack, Golden Pineapple, and K2 are other strains good for this disorder.

Spruce’s 2,400 mg full-spectrum CBD delivers 80 mg of CBD per 1 milliliter (ml) dose,
which is equivalent to a full dropper.

Health Canal avoids using tertiary references. We have strict sourcing guidelines and rely on peer-reviewed studies, academic researches from medical associations and institutions. To ensure the accuracy of articles in Health Canal, you can read more about the editorial process here

  1. Crohn’s & Colitis Foundation. (2020). What Is Crohn’s Disease? Available from: https://www.crohnscolitisfoundation.org/what-is-crohns-disease.
  2. Crohn’s and Colitis. (2016). WHAT ARE SYMPTOMS OF CROHN’S DISEASE? Available from: https://www.crohnsandcolitis.com/crohns/disease-symptoms‌.
  3. Expert Review of Gastroenterology & Hepatology. (2020). An overview of cannabis based treatment in Crohn’s disease. Available from: https://www.tandfonline.com/doi/abs/10.1080/17474124.2020.1740590‌.
  4. Naftali, T., Bar-Lev Schleider, L., Sklerovsky Benjaminov, F., Lish, I., Konikoff, F.M. and Ringel, Y. (2019). Medical cannabis for inflammatory bowel disease. European Journal of Gastroenterology & Hepatology. Available from: https://pubmed.ncbi.nlm.nih.gov/31567639/.‌
  5. Hoffenberg, E.J., McWilliams, S., Mikulich-Gilbertson, S., Murphy, B., Hoffenberg, A. and Hopfer, C.J. (2019). Cannabis Oil Use by Adolescents and Young Adults With Inflammatory Bowel Disease. Journal of Pediatric Gastroenterology and Nutrition, 68(3), 348–352. Available from: https://journals.lww.com/jpgn/FullText/2019/03000/Cannabis_Oil_Use_by_Adolescents_and_Young_Adults.16.aspx.‌
  6. Barrie, N. and Manolios, N. (2017). The endocannabinoid system in pain and inflammation: Its relevance to rheumatic disease. European Journal of Rheumatology, 4(3), 210–218. Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5685274/.
  7. Naftali, T., Mechulam, R., Marii, A., Gabay, G., Stein, A., Bronshtain, M., Laish, I., Benjaminov, F. and Konikoff, F.M. (2017). Low-Dose Cannabidiol Is Safe but Not Effective in the Treatment for Crohn’s Disease, a Randomized Controlled Trial. Digestive Diseases and Sciences, 62(6), 1615–1620. Available from: https://pubmed.ncbi.nlm.nih.gov/28349233/.
  8. ‌Schicho, R. and Storr, M. (2012). Topical and Systemic Cannabidiol Improves Trinitrobenzene Sulfonic Acid Colitis in Mice. Pharmacology, 89(3–4), 149–155. Available at: https://pubmed.ncbi.nlm.nih.gov/22414698/.‌
  9. Jamontt, J., Molleman, A., Pertwee, R. and Parsons, M. (2010). The effects of Δ9-tetrahydrocannabinol and cannabidiol alone and in combination on damage, inflammation andin vitromotility disturbances in rat colitis. British Journal of Pharmacology, 160(3), 712–723. Available from: https://pubmed.ncbi.nlm.nih.gov/20590574/.‌
  10. Leinwand, K.L., Gerich, M.E., Hoffenberg, E.J. and Collins, C.B. (2017). Manipulation of the Endocannabinoid System in Colitis. Inflammatory Bowel Diseases, 23(2), 192–199. Available at: https://pubmed.ncbi.nlm.nih.gov/28079617/.
  11. Alhouayek, M. and Muccioli, G.G. (2012). The endocannabinoid system in inflammatory bowel diseases: from pathophysiology to therapeutic opportunity. Trends in Molecular Medicine, 18(10), 615–625. Available from: https://pubmed.ncbi.nlm.nih.gov/22917662/.‌
  12. Karoly, H.C., Mueller, R.L., Bidwell, L.C. and Hutchison, K.E. (2019). Cannabinoids and the Microbiota–Gut–Brain Axis: Emerging Effects of Cannabidiol and Potential Applications to Alcohol Use Disorders. Alcoholism: Clinical and Experimental Research, 44(2), 340–353. Available from: https://pubmed.ncbi.nlm.nih.gov/31803950/.
  13. ‌Price, S. (2020). CBD and inflammatory bowel disease: not just a gut feeling. Health Europa. Available from: https://www.healtheuropa.eu/icbd-cbd-formulation-ibd/100721/.
Kathy Shattler, MS, RDN

Kathy Shattler has been a Registered Dietitian for over 25 years and currently runs her own Telehealth Clinic while freelance writing in her spare time. She graduated with a Master of Science degree in Human Nutrition from Michigan State University and has a plethora of experience in both clinical nutrition as well as public health. She has been deemed a trailblazer in her profession and continues to strive for excellence in public health education in integrative medicine and in her professional writing career.

Having crohn's disease doesn't mean you have to deal with its symptoms. Here are the best CBD oil dosage for crohn's disease in 2021!