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CBD vs. THC: What’s the difference?

Cannabis consumers have long prized potency (a high THC content) as one of the main factors that makes a particular strain more desirable. Though traditional demand for THC has caused an oversaturation of high-potency products, many consumers are starting to prefer less intense products that are lower in THC and higher in the non-intoxicating compound called CBD (cannabidiol).

What’s the difference between CBD and THC?

THC and CBD are both cannabinoids derived from the cannabis plant, but they’re different in many ways that may influence your next dispensary purchase.

An easy way to think about it is that THC is defined by what cannabis makes you feel, while the effects of CBD can’t be felt. The important distinction is that, unlike THC, CBD will not intoxicate you. It also addresses one of the most common reasons people choose to use CBD—pain management.

CBD can also block some of the intoxicating effects of THC. By binding to cannabinoid receptors, it will keep THC from activating those receptors. This translates to a less intense psychoactive effect, which is why products with a mix of CBD and THC are great for first-time consumers.

This does not mean that CBD, by itself, cannot offer an effect. High doses of CBD often produce a profoundly relaxing experience. Like stepping out of a hot tub, your body may feel tingly and relaxed, and your brain may be clear.

CBD vs. THC: legality

With the passing of the Farm Bill in December 2018, industrial hemp became a legal agricultural commodity in all 50 states. While the DEA still considers CBD to be a Schedule I controlled substance, it clarified in a memo that trace amounts of CBD found in hemp stalks or seeds were legal.

However, the legality of hemp-derived CBD may vary from state to state, so it’s important to check your state’s laws before stocking up on hemp-derived CBD products.

Cannabis strains that have a high CBD:THC ratio are legal only in states with legal, regulated cannabis markets.

What are the medicinal effects of CBD?

The list of conditions CBD may help with is ever-expanding. More research is needed to better understand the efficacy and range of CBD’s benefits, but it’s popularly used to manage the following symptoms and conditions:

  • Epilepsy and seizure disorders
  • Pain and inflammation
  • PTSD and anxiety
  • Crohn’s disease
  • Multiple sclerosis
  • Opioid withdrawal

Though clinical and anecdotal evidence suggests CBD can help manage different conditions, CBD became most famous for treating a rare and debilitating form of pediatric epilepsy.

Dravet’s Syndrome is notoriously resistant to current treatment methods. People with the condition are plagued by seizures, often up to hundreds a day, and they usually worsen as people age and can be life-threatening. Currently, treatment methods include having a child wear an eyepatch, specialized diets, and brain surgery, but all have mixed success rates.

One of the earliest success stories involves a young girl named Charlotte who was given an ingestible oil derived from Charlotte’s Web , a CBD strain that was specifically developed to provide her with all the benefits of the drug without the high.

In less than two years, Charlotte went from a monthly seizure count of 1,200 to about three. Other success stories followed and more parents have begun to speak out, particularly parents desperate for access to this life-saving treatment.

CBD has no lethal dose or known serious side effects. The idea of using cannabis-derived compounds for pediatric conditions remains a touchy subject in a culture where cannabis has been stigmatized.

If you would like to know more about the benefits of CBD, check out our CBD Guide.

Although THC is best known for its mind-altering euphoria, it too has important medical benefits. There’s some overlap in what CBD and THC can treat, but THC is particularly effective in relieving nausea, appetite loss, insomnia, among other symptoms. Many patients find that a balance of CBD and THC offers the best symptom relief as the two work together synergistically.

What are some high-CBD strains I can try?

CBD is typically the second-most abundant cannabinoid in cannabis, but this isn’t always the case. A strain may deliver CBD and THC in the following ratios:

  • High THC, low CBD (e.g.,10-30% THC, trace amounts of CBD)
  • Balanced CBD/THC (e.g., 5-15% THC and 5-15% CBD)
  • High CBD, low THC (e.g., 5-20% CBD, THC under 5%)

(The Cannabiz Agency/iStock)

High-CBD strains tend to deliver very clear-headed, functional effects without the euphoric high associated with high-THC strains. They’re typically preferred by consumers who are extremely sensitive to the side effects of THC (e.g., anxiety, paranoia, dizziness).

A high-CBD strain would also be a great choice for someone needing to medicate throughout the day to control pain, inflammation, anxiety, or other chronic conditions.

Balanced CBD/THC strains will be a little more euphoric than CBD-dominant strains, though they’re much less likely to induce anxiety, paranoia, and other negative side effects. Strains like these tend to be the most effective for pain relief, and they’re also well-suited for THC-sensitive consumers who’d like a mellow buzz.

CBD strains can be consumed just as you would THC strains. You can smoke or vaporize CBD-rich flower, eat a CBD-infused edible, swallow a CBD oil capsule, apply a CBD lotion, or use a CBD tincture sublingually. Hemp products also contain CBD, though it is a less efficient source and lacks the beneficial chemical diversity of cannabis-derived CBD products (more on that here).

Keep in mind that CBD levels may vary from crop to crop—even from plant to plant. We also recommend checking with dispensaries about the specifics of their strains’ CBD levels. It’s always a good idea to purchase only lab-tested products that clearly state the CBD/THC levels so you know what kind of experience to expect.

This post was originally published on July 3, 2018. It was most recently updated on April 1, 2020.

CBD and THC are both derived from cannabis plants, but they’re very different. Learn the difference between CBD and THC.

Does CBD Counteract THC’s Psychoactive Effect?

THC and CBD are the two most common cannabinoids, and they share a nuanced and special relationship. Read on to discover if CBD helps to minimise the negative effects of THC, and find out which CBD:THC ratio is best for you.

Can CBD tame THC’s psychoactive effect?

Contents:

The cannabis plant produces hundreds of different phytochemicals belonging to several families—cannabinoids, terpenes, flavonoids, and others. Among these, the cannabinoids THC and CBD stand out as the most sought-after chemicals.

All these cannabis constituents have their own purposes, but their effects tend to be more profound when combined. This chemical synergy is known as the entourage effect. According to this theory, not only do cannabinoids like THC and CBD synergise, but terpenes and other compounds as well. When it comes to our star cannabinoids, can CBD counteract or tame the psychoactive effect of THC? Find out below.

CBD VS THC

CBD and THC are the two most common cannabinoids encountered in modern cultivars. Although both produce beneficial effects, they feature a stark difference—THC is psychoactive, whereas CBD is not.

THC underpins the high produced by the cannabis plant. The molecule induces the often euphoric, enjoyable, and relaxing effects associated with smoking, eating, or vaping cannabis. However, THC can also pack some undesirable effects, giving rise to paranoia and even panic in inexperienced or unprepared users.

The secret behind these effects? THC binds to CB1 receptors of the endocannabinoid system like a key fits into a lock. These sites exist throughout the central nervous system; once activated, a series of chemical changes occur that give rise to an altered state of consciousness.

Researchers are just beginning to understand how CBD works in the body. Like THC, CBD also interacts with the endocannabinoid system. However, it does so in a different manner. The molecule doesn’t bind to cannabinoid receptors with much affinity. The fact that it doesn’t latch onto the CB1 receptor explains why CBD doesn’t produce a psychoactive effect.

Instead, CBD raises levels of endocannabinoids—including anandamide (often dubbed the “bliss molecule”)—that bind to native cannabinoid receptors. CBD also targets serotonin, TRPV1, GPR55, and PPAR receptors to produce its effects.

Through these pathways, researchers have found CBD to produce various outcomes. The cannabinoid appears to help individuals when they are feeling nervous and pressured [1] , and it may help soothe sensitive skin [2] and ease sore muscles [3] .

THC CBD

MIXING CBD WITH THC

Combining CBD and THC offers myriad benefits. Not only will it help tame the high, but the two cannabinoids appear to work better side by side. One of the easiest ways to consume both molecules at the same time is with a good old fashioned smoke. Select a strain that features equal parts THC and CBD and fire it up. These varieties provide enough THC to kickstart your CB1 receptors alongside adequate levels of CBD to stave off any adverse effects.

If you find you’re extra-sensitive to THC, try a CBD-rich strain with much lower levels of THC. You’ll still experience the effects of both cannabinoids, just with less of a high.

You can also try combining CBD oils with smoking and vaping. Inhale some THC-rich weed and keep a bottle of CBD oil nearby to modulate the high as you go. If the effects become too much, place a few drops under the tongue and wait for it to be absorbed.

Likewise, take several drops before your smoke to buffer against the psychoactive effects before they take hold. Taking CBD in this manner will enable you to dose accurately and readily.

CBD and THC each have powerful potential of their own, but what happens when you combine them? Can CBD tame THC's psychoactive effect? Find out inside!